Solerte S B, Fioravanti M
Department of Internal Medicine and Medical Therapy, University of Pavia, Italy.
Clin Nephrol. 1987 Sep;28(3):138-43.
The possible relationship among blood rheology pattern, renal hemodynamics and proteinuria was investigated in 22 long-term insulin-dependent diabetic patients with overt nephropathy. Higher blood, plasma and serum viscosity and lower erythrocyte filtrability were found in our patients with overt nephropathy, than in patients without renal microvascular complications. Several negative correlations between blood viscosity and renal hemodynamic parameters (i.e., glomerular filtration rate and renal plasma flow) were demonstrated in the diabetics with overt nephropathy. Furthermore increased plasma fibrinogen, fibronectin and acute-phase protein levels were found in diabetics with overt nephropathy, compared to diabetics without renal changes. The data may suggest a pathogenetic role for blood rheology changes in the progression of diabetic glomerular complications.
在22例患有显性肾病的长期胰岛素依赖型糖尿病患者中，研究了血液流变学模式、肾脏血流动力学和蛋白尿之间可能存在的关系。与无肾脏微血管并发症的患者相比，我们的显性肾病患者血液、血浆和血清粘度更高，红细胞滤过率更低。在患有显性肾病的糖尿病患者中，血液粘度与肾脏血流动力学参数（即肾小球滤过率和肾血浆流量）之间存在几种负相关关系。此外，与无肾脏改变的糖尿病患者相比，患有显性肾病的糖尿病患者血浆纤维蛋白原、纤连蛋白和急性期蛋白水平升高。这些数据可能提示血液流变学改变在糖尿病肾小球并发症进展中具有致病作用。
