Spinelli L, Ferro G, Nappi C, Farace M J, Talarico G, Cinquegrana G, Condorelli M
Department of Internal Medicine, Second School of Medicine, University of Naples, Italy.
Clin Cardiol. 1987 Oct;10(10):567-72. doi: 10.1002/clc.4960101011.
Early diastolic time intervals have been assessed by means of the echopolycardiographic method in 17 pregnant women who developed hypertension during pregnancy (HP) and in 14 normal pregnant women (N). Systolic time intervals (STI), stroke volume (SV), ejection fraction (EF), and mean velocity of myocardial fiber shortening (VCF) were also evaluated. Recordings were performed in the left lateral decubitus (LLD) and then in the supine decubitus (SD). In LLD, isovolumic relaxation period (IRP) was prolonged in the hypertensive pregnant women compared with normal pregnant women (HP 51 +/- 12.5 ms, N 32.4 +/- 15 ms p less than 0.05), whereas time of the mitral valve maximum opening (DE) was not different in the groups. There was no difference in SV, EF, and mean VCF, whereas STI showed only a significant (p less than 0.05) lengthening of pre-ejection period (PEP) in HP. When the subjects shifted from the left lateral to the supine decubitus position, left ventricular ejection time index (LVETi) and SV decreased significantly (p less than 0.05) in both normotensive hypertensive pregnant women. IRP and PEP lengthened significantly (p less than 0.05) only in normals, whereas they were unchanged in HP. DE time did not vary in either group. In conclusion, hypertension superimposed on pregnancy induces lengthening of IRP, as well as of PEP, and minimizes the effects of the postural changes in preload on the above-mentioned time intervals.
采用超声心动图方法对17例妊娠期高血压（HP）孕妇和14例正常孕妇（N）的舒张早期时间间期进行了评估。还评估了收缩时间间期（STI）、每搏输出量（SV）、射血分数（EF）和心肌纤维缩短平均速度（VCF）。记录在左侧卧位（LLD）和仰卧位（SD）进行。在左侧卧位时，高血压孕妇的等容舒张期（IRP）较正常孕妇延长（HP为51±12.5毫秒，N为32.4±15毫秒，p<0.05），而两组二尖瓣最大开放时间（DE）无差异。SV、EF和平均VCF无差异，而STI仅显示HP组射血前期（PEP）显著延长（p<0.05）。当受试者从左侧卧位转为仰卧位时，正常孕妇和高血压孕妇的左心室射血时间指数（LVETi）和SV均显著降低（p<0.05）。IRP和PEP仅在正常孕妇中显著延长（p<0.05），而在HP组中无变化。两组的DE时间均无变化。总之，妊娠期并发高血压会导致IRP和PEP延长，并使前负荷的体位变化对上述时间间期的影响最小化。
