Konnai Masaki, Yamamoto Masami, Ito Keiko, Yamabe Hanae, Kishimoto Takuya E, Aoki Hiroshi, Machida Yukino, Michishita Masaki, Haritani Makoto, Yoshimura Hisashi
Laboratory of Veterinary Pathology, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.
Laboratory of Physiological Pathology, Department of Applied Science, School of Veterinary Nursing and Technology, Nippon Veterinary and Life Science University, Tokyo, Japan.
J Comp Pathol. 2023 Feb;201:23-27. doi: 10.1016/j.jcpa.2022.12.008. Epub 2023 Jan 16.
The Amami rabbit (Pentalagus furnessi) is found only on the two islands of Amami-Ōshima and Tokunoshima in southwest Japan. It has a primitive appearance and ecology, is an evolutionarily valuable animal and has been assigned to the International Union for Conservation of Nature Red List of Threatened Species. We describe a case with mild purulent wounds on the distal digital skin of both forelimbs and multiple nodular lesions in various organs, including the heart and kidney. Microscopically, the heart lesions were characterized by disruption of the mitral valve and multifocal myocardial necrosis and abscesses due to infection with gram-positive cocci. Similar bacterial infarctions were also found in other organs, including the kidneys. The bacteria were identified as Staphylococcus aureus by immunohistochemical and molecular biological examinations. This first report of infective endocarditis and systemic infarctions caused by S. aureus in an Amami rabbit indicates the importance of monitoring purulent injuries, even if mild, to prevent secondary infections in this species.
奄美兔（Pentalagus furnessi）仅分布于日本西南部的奄美大岛和德之岛这两个岛屿。它具有原始的外观和生态习性，是一种具有进化价值的动物，已被列入国际自然保护联盟濒危物种红色名录。我们描述了一例病例，该病例的两只前肢指端皮肤有轻度脓性伤口，心脏和肾脏等多个器官出现多发结节性病变。显微镜下，心脏病变的特征是二尖瓣破坏以及由于革兰氏阳性球菌感染导致的多灶性心肌坏死和脓肿。在包括肾脏在内的其他器官中也发现了类似的细菌性梗死。通过免疫组织化学和分子生物学检查，这些细菌被鉴定为金黄色葡萄球菌。这是关于奄美兔由金黄色葡萄球菌引起感染性心内膜炎和全身性梗死的首次报告，表明即使是轻度的脓性损伤，监测其对于预防该物种的继发感染也很重要。
