Max-Planck-Institute for Metabolism Research, Gleueler Str. 50, 50931 Cologne, Germany; University of Cologne, Faculty of Medicine and University Hospital Cologne, Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEPD), Kerpener Str. 62, 50937 Cologne, Germany.
Max-Planck-Institute for Metabolism Research, Gleueler Str. 50, 50931 Cologne, Germany.
Cell Rep Med. 2023 Jan 17;4(1):100897. doi: 10.1016/j.xcrm.2022.100897.
Feeding behavior must be continuously adjusted to match energy needs. Recent discoveries in murine models identified uridine as a regulator of energy balance. Here, we explore its contribution to the complex control of food intake in humans by administering a single dose of uridine monophosphate (UMP; 0.5 or 1 g) to healthy participants in two placebo-controlled studies designed to assess food behavior (registration: DRKS00014874). We establish that endogenous circulating uridine correlates with hunger and ensuing food consumption. It also dynamically decreases upon caloric ingestion, prompting its potential role in a negative feedback loop regulating energy intake. We further demonstrate that oral UMP administration temporarily increases circulating uridine and-when within the physiological range-enhances hunger and caloric intake proportionally to participants' basal energy needs. Overall, uridine appears as a potential target to tackle dysfunctions of feeding behavior in humans.
进食行为必须不断调整以适应能量需求。最近在鼠类模型中的发现表明尿苷是能量平衡的调节剂。在这里，我们通过在两项安慰剂对照研究中向健康参与者单次给予尿苷单磷酸（UMP；0.5 或 1 g）来探索其对人类复杂的摄食控制的贡献，这些研究旨在评估食物行为（注册：DRKS00014874）。我们确定内源性循环尿苷与饥饿和随后的食物消耗相关。它还会在摄入热量时动态减少，提示其在调节能量摄入的负反馈回路中具有潜在作用。我们进一步证明，口服 UMP 给药会暂时增加循环尿苷，并且在生理范围内增加饥饿感，并与参与者的基础能量需求成比例地增加热量摄入。总的来说，尿苷似乎是解决人类进食行为功能障碍的潜在靶点。
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