Sia S T, Holman B L, Campbell S, Lister-James J, English R J, Kronauge J F, Davison A, Jones A G
Department of Medicine, Harvard Medical School, Boston, Massachusetts.
Clin Nucl Med. 1987 Sep;12(9):681-7. doi: 10.1097/00003072-198709000-00001.
Myocardial perfusion imaging with Tc-99m carbomethoxyisopropylisonitrile (CPI) was compared with Tl-201 imaging in 22 patients who were assessed for coronary artery disease. There was agreement between Tc-99m CPI and Tl-201 imaging for detecting segmental myocardial ischemia and fixed defects in 185/198 (93%) of left ventricular segments. There was also an excellent correlation between the two tracers for the detection of coronary artery disease (18/22 patients). Myocardial clearance of the isonitrile complex was slow, and there was no redistribution into ischemic regions; the normal to ischemic myocardial ratio remained relatively constant over time. Reinjection at rest was used to distinguish transient ischemia from infarction. The isonitrile complex was excreted rapidly via the hepatobiliary system. After 3 hours, background activity was reduced to about 20% of the initial activity. Tc-99m CPI appears comparable to Tl-201 thallous chloride for detecting coronary artery disease. Tc-99m CPI may be useful as a myocardial imaging agent because there is no myocardial redistribution, myocardial clearance is slow, and clearance from background tissues is rapid.
在22例接受冠状动脉疾病评估的患者中，对锝-99m甲氧基异丁基异腈（CPI）心肌灌注显像与铊-201显像进行了比较。锝-99m CPI与铊-201显像在检测198个左心室节段中的185个（93%）节段性心肌缺血和固定缺损方面具有一致性。在检测冠状动脉疾病方面（18/22例患者），这两种示踪剂之间也具有良好的相关性。异腈复合物的心肌清除缓慢，且无再分布至缺血区域；正常心肌与缺血心肌的比值随时间保持相对恒定。静息时再注射用于区分短暂性缺血与梗死。异腈复合物通过肝胆系统迅速排泄。3小时后，本底活性降至初始活性的约20%。锝-99m CPI在检测冠状动脉疾病方面似乎与氯化铊-201相当。锝-99m CPI可能作为一种心肌显像剂有用，因为不存在心肌再分布，心肌清除缓慢，且从本底组织的清除迅速。
