Ali Saif, Alam Roshan, Ahsan Haseeb, Khan Saba
Department of Biochemistry, Integral Institute of Medical Sciences and Research, Integral University, Lucknow, India.
Department of Biochemistry, Faculty of Dentistry, Jamia Millia Islamia, Jamia Nagar, New Delhi, India.
Nutr Metab Cardiovasc Dis. 2023 Mar;33(3):483-493. doi: 10.1016/j.numecd.2022.11.023. Epub 2022 Nov 29.
Adipose tissue is considered as an endocrine organ that releases bioactive factors known as adipokines which contribute to the pathogenesis of rotundity-linked metabolic and cardiovascular complications. Rotundity is a major predisposer for the development and progression of coronary artery disease (CAD).
The literature survey from various databases such as Pubmed/Medline, DOAJ, Scopus, Clarivate analytics/Web of Science and Google Scholar were used to prepare this article. The epidemic of rotundity has gained significant attention to understand the biology of adipocytes and the metabolism of adipose tissue in obese individuals. In CAD, visfatin/NAMPT was primarily indicated as a clinical marker of atherosclerosis, endothelial dysfunction and vascular injury having a prognostic significance. Visfatin/NAMPT is a factor that promotes vascular inflammation and atherosclerosis. Omentin is an anti-inflammatory and anti-atherogenic adipokine regulating cardiovascular functions.
This review highlights and summarizes the scientific information pertaining to the role of the adipokines - omentin and visfatin in CAD.
脂肪组织被视为一种内分泌器官，可释放被称为脂肪因子的生物活性因子，这些因子会导致与肥胖相关的代谢和心血管并发症的发病机制。肥胖是冠状动脉疾病（CAD）发生和发展的主要诱因。
本文通过对多个数据库（如Pubmed/Medline、DOAJ、Scopus、科睿唯安分析/科学网和谷歌学术）进行文献检索来撰写。肥胖的流行已引起人们对肥胖个体脂肪细胞生物学和脂肪组织代谢的高度关注。在CAD中，内脂素/烟酰胺磷酸核糖转移酶（visfatin/NAMPT）主要被视为动脉粥样硬化、内皮功能障碍和血管损伤的临床标志物，具有预后意义。内脂素/烟酰胺磷酸核糖转移酶是一种促进血管炎症和动脉粥样硬化的因子。网膜素是一种调节心血管功能的抗炎和抗动脉粥样硬化脂肪因子。
本综述重点介绍并总结了有关脂肪因子——网膜素和内脂素在CAD中作用的科学信息。
