Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
Department of Electrical & Computer Engineering, University of Maryland, College Park, MD, USA.
Transl Psychiatry. 2023 Jan 19;13(1):13. doi: 10.1038/s41398-022-02300-6.
Aberrant gamma frequency neural oscillations in schizophrenia have been well demonstrated using auditory steady-state responses (ASSR). However, the neural circuits underlying 40 Hz ASSR deficits in schizophrenia remain poorly understood. Sixty-six patients with schizophrenia spectrum disorders and 85 age- and gender-matched healthy controls completed one electroencephalography session measuring 40 Hz ASSR and one imaging session for resting-state functional connectivity (rsFC) assessments. The associations between the normalized power of 40 Hz ASSR and rsFC were assessed via linear regression and mediation models. We found that rsFC among auditory, precentral, postcentral, and prefrontal cortices were positively associated with 40 Hz ASSR in patients and controls separately and in the combined sample. The mediation analysis further confirmed that the deficit of gamma band ASSR in schizophrenia was nearly fully mediated by three of the rsFC circuits between right superior temporal gyrus-left medial prefrontal cortex (MPFC), left MPFC-left postcentral gyrus (PoG), and left precentral gyrus-right PoG. Gamma-band ASSR deficits in schizophrenia may be associated with deficient circuitry level connectivity to support gamma frequency synchronization. Correcting gamma band deficits in schizophrenia may require corrective interventions to normalize these aberrant networks.
精神分裂症患者的异常伽马频率神经振荡已经通过听觉稳态反应 (ASSR) 得到了很好的证明。然而，精神分裂症中 40Hz ASSR 缺陷的神经回路仍然知之甚少。66 名精神分裂症谱系障碍患者和 85 名年龄和性别匹配的健康对照者完成了一个脑电图测量 40Hz ASSR 的会议和一个用于静息状态功能连接 (rsFC) 评估的成像会议。通过线性回归和中介模型评估了 40Hz ASSR 的归一化功率与 rsFC 之间的关联。我们发现，患者和对照组以及合并样本中，听觉、中央前回、中央后回和前额叶皮质之间的 rsFC 与 40Hz ASSR 呈正相关。中介分析进一步证实，精神分裂症中伽马频段 ASSR 的缺陷几乎完全由右颞上回-左内侧前额叶皮质（MPFC）、左 MPFC-左中央后回（PoG）和左中央前回-右 PoG 之间的三个 rsFC 回路来介导。精神分裂症中伽马波段 ASSR 缺陷可能与支持伽马频率同步的回路水平连通性不足有关。纠正精神分裂症中的伽马频带缺陷可能需要纠正干预措施来使这些异常网络正常化。
