Gontarz N, Small R E, Comstock T J, Stalker D J, Johnson S M, Willis H E
Medical College of Virginia-Virginia Commonwealth University, Richmond 23298-0001.
Clin Pharm. 1987 May;6(5):413-6.
The effect of antacid administration on the pharmacokinetics of ibuprofen was evaluated in a randomized, crossover study of eight healthy volunteers. Doses of 62 mL of aluminum and magnesium hydroxide suspension and single doses of ibuprofen 400 mg were used. Subjects received each of the following treatments at one-week intervals: ibuprofen alone; ibuprofen administered concurrently with one dose of antacid; antacid administered one hour after the ibuprofen dose; and antacid administered concurrently with the ibuprofen dose, plus three more antacid doses given every five hours. Blood samples were taken at various time intervals up to 24 hours after the ibuprofen dose. Serum samples were assayed for ibuprofen content using high-performance liquid chromatography. Values for AUC, Cmax, tmax, and k were not significantly different among treatment groups. The ranges of mean (+/- S.D.) values were 113.97 +/- 21.5 to 127.53 +/- 29.3 micrograms.hr/mL for AUC, 35.30 +/- 6.40 to 41.00 +/- 10.00 micrograms/mL for Cmax, 0.95 +/- 0.30 to 1.28 +/- 0.54 hr for tmax, and 0.346 +/- 0.026 to 0.388 +/- 0.040 hr-1 for k. For the doses used, concurrent administration of aluminum and magnesium hydroxide suspension and ibuprofen does not alter ibuprofen pharmacokinetics.
在一项针对8名健康志愿者的随机交叉研究中，评估了服用抗酸剂对布洛芬药代动力学的影响。使用了62毫升氢氧化铝和氢氧化镁混悬液的剂量以及400毫克布洛芬的单次剂量。受试者每隔一周接受以下每种治疗：单独服用布洛芬；布洛芬与一剂抗酸剂同时服用；在服用布洛芬剂量1小时后服用抗酸剂；布洛芬剂量与抗酸剂同时服用，外加每5小时再服用三剂抗酸剂。在服用布洛芬剂量后的24小时内，在不同时间间隔采集血样。使用高效液相色谱法测定血清样本中的布洛芬含量。各治疗组之间的AUC、Cmax、tmax和k值无显著差异。AUC的平均（±标准差）值范围为113.97±21.5至127.53±29.3微克·小时/毫升，Cmax为35.30±6.40至41.00±10.00微克/毫升，tmax为0.95±0.30至1.28±0.54小时，k为0.346±0.026至0.388±0.040小时⁻¹。对于所使用的剂量，同时服用氢氧化铝和氢氧化镁混悬液与布洛芬不会改变布洛芬的药代动力学。
