Department of Pharmaceutics, Government College of Pharmacy, Karad, Shivaji University, Karad, 415004, India.
Pharm Nanotechnol. 2023 Jun 6;11(3):217-237. doi: 10.2174/2211738511666230118095936.
Diabetes mellitus (DM) is a life-threatening multifactorial metabolic syndrome that is still one of the most difficult unsolved health concerns. Different herbal drugs have been proposed to be useful in treating diabetes and its associated complications. Two major obstacles in plant extracts are their limited solubility and bioavailability of lipophilic bioactive components. Applying nanotechnology has opened new avenues to improve solubility, bioavailability, compliance, and efficacy by overcoming the pharmacokinetic and biopharmaceutical obstacles associated with herbal extracts and phytochemicals. Herbal nanomedicines can overcome the drawbacks of conventional therapy of DM, its complications like delayed wound healing, and also decrease the side effects of synthetic drugs. The targeted delivery of herbal nanoparticles employing nano-pumps, nanorobots, smart cells, and nanosized herbal medications is recognized today as one of the most far-reaching discoveries in the therapy of DM. This paper focuses on using nanotechnology and herbal therapies to manage diabetes effectively. The review provides a detailed and up-to-date overview of phytonanoformulations in treating diabetes and its consequences.
糖尿病（DM）是一种危及生命的多因素代谢综合征，仍然是最具挑战性的未解决的健康问题之一。不同的草药药物已被提议用于治疗糖尿病及其相关并发症。植物提取物的两个主要障碍是其有限的亲脂性生物活性成分的溶解度和生物利用度。应用纳米技术为提高溶解度、生物利用度、顺应性和功效开辟了新途径，克服了与草药提取物和植物化学物质相关的药代动力学和生物制药障碍。草药纳米药物可以克服糖尿病常规治疗的缺点，如延迟伤口愈合，并减少合成药物的副作用。今天，使用纳米泵、纳米机器人、智能细胞和纳米大小的草药药物靶向输送草药纳米粒子被认为是糖尿病治疗中最具深远意义的发现之一。本文重点介绍了使用纳米技术和草药疗法来有效管理糖尿病。该综述详细介绍了植物纳米制剂在治疗糖尿病及其后果方面的最新进展。
