Institute of Pharmacy, Nirma University, Ahmedabad, India.
Non-Destructive Biomedical and Pharmaceutical Research Centre, Smart Manufacturing Research Institute, Universiti Teknologi MARA Selangor, Puncak Alam, Malaysia.
Expert Opin Drug Deliv. 2024 Jul;21(7):1115-1141. doi: 10.1080/17425247.2024.2388214. Epub 2024 Aug 8.
Wound healing is an intricate and continual process influenced by numerous factors that necessitate suitable environments to attain healing. The natural ability of wound healing often gets altered by several external and intrinsic factors, leading to chronic wound occurrence. Numerous wound dressings have been developed; however, the currently available alternatives fail to coalesce in all conditions obligatory for rapid skin regeneration.
An extensive review of articles on herbal nano-composite wound dressings was conducted using PubMed, Scopus, and Google Scholar databases, from 2006 to 2024. This review entails the pathophysiology and factors leading to non-healing wounds, wound dressing types, the role of herbal bio-actives for wound healing, and the advantages of employing nanotechnology to deliver herbal actives. Numerous nano-composite wound dressings incorporated with phytoconstituents, herbal extracts, and essential oils are discussed.
There is a strong substantiation that several herbal bio-actives possess anti-inflammatory, antimicrobial, antioxidant, analgesic, and angiogenesis promoter activities that accelerate the wound healing process. Nanotechnology is a promising strategy to deliver herbal bio-actives as it ascertains their controlled release, enhances bioavailability, improves permeability to underlying skin layers, and promotes wound healing. A combination of herbal actives and nano-based dressings offers a novel arena for wound management.
伤口愈合是一个复杂而持续的过程，受到许多因素的影响，需要合适的环境才能实现愈合。伤口愈合的自然能力常常会被许多外部和内在因素改变，导致慢性伤口的发生。已经开发出了许多伤口敷料，但目前可用的替代品在所有必需的条件下都无法协同作用，以实现快速皮肤再生。
使用 PubMed、Scopus 和 Google Scholar 数据库，对 2006 年至 2024 年期间有关草药纳米复合伤口敷料的文章进行了广泛的综述。本综述涉及导致伤口愈合不良的病理生理学和因素、伤口敷料类型、草药生物活性在伤口愈合中的作用，以及纳米技术用于输送草药活性的优势。讨论了许多与植物成分、草药提取物和精油结合的纳米复合伤口敷料。
有充分的证据表明，许多草药生物活性具有抗炎、抗菌、抗氧化、镇痛和促进血管生成的作用，可加速伤口愈合过程。纳米技术是输送草药生物活性的一种很有前途的策略，因为它可以确保其控制释放、提高生物利用度、增加对底层皮肤层的渗透性，并促进伤口愈合。草药活性物与基于纳米的敷料的结合为伤口管理提供了一个新的领域。
