Zafari Nima, Velayati Mahla, Mehrabadi Shima, Damavandi Sedigheh, Khazaei Majid, Hassanian Seyed Mahdi, Ferns Gordon A, Avan Amir
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Division of Medical Education, Brighton & Sussex Medical School, Falmer, Brighton, Sussex, BN1 9PH, UK.
Curr Pharm Des. 2023;29(4):256-271. doi: 10.2174/1381612829666230118123018.
The considerable burden of colorectal cancer and the increasing prevalence in young adults emphasizes the necessity of understanding its underlying mechanisms and risk factors as well as providing more effective treatments. There is growing evidence of a positive relationship between obesity and colorectal cancer. Furthermore, the prominent role of gut microbiota dysbiosis in colorectal carcinogenesis is becoming more evident. Sequencing studies demonstrate an altered composition and ecology of intestinal microorganisms in both colorectal cancer and obese patients and have pinpointed some specific bacteria as the key role players. The purpose of this review is to provide a general outlook of how gut microbiota may impact the initiation and promotion of colorectal cancer and describes probable links between gut microbiota and obesity. We also provide evidence about targeting the microbiota as an intervention strategy for both ameliorating the risk of cancer and augmenting the therapy efficacy.
结直肠癌的沉重负担以及在年轻人中日益增加的患病率凸显了了解其潜在机制和风险因素以及提供更有效治疗方法的必要性。越来越多的证据表明肥胖与结直肠癌之间存在正相关关系。此外，肠道微生物群失调在结直肠癌发生过程中的突出作用正变得越来越明显。测序研究表明，结直肠癌患者和肥胖患者的肠道微生物组成和生态都发生了改变，并确定了一些特定细菌为关键参与者。本综述的目的是概述肠道微生物群如何影响结直肠癌的发生和发展，并描述肠道微生物群与肥胖之间可能存在的联系。我们还提供了以微生物群为靶点作为干预策略以降低癌症风险和提高治疗效果的证据。
