Microbial Screening Technologies Pty. Ltd., Smithfield, NSW 2164, Australia.
School of Natural Sciences, Macquarie University, Sydney, NSW 2109, Australia.
J Nat Prod. 2023 Mar 24;86(3):633-637. doi: 10.1021/acs.jnatprod.2c00989. Epub 2023 Jan 18.
The myxomycete , colloquially referred to as "dog vomit fungus", forms vibrant yellow fruiting bodies (aethalia) on wood chips during warm and humid conditions in spring. In 2018, ideal climatic conditions in Sydney, Australia, provided a rare opportunity to access abundant quantities of aethalia, which enabled the isolation, purification, structure elucidation, and biological screening of two avenalumamide pyrones, fuligopyrone () and fuligopyrone B (). While and did not exhibit any appreciable biological activity, their significant UV absorption at 325 nm suggested they may be acting as transient sunscreens to help protect the fruiting mass from exposure to sunlight. In support of this hypothesis, exposing a solution of to direct sunlight for 5 min resulted in rapid equilibration with a mixture of 2,4-fuligopyrone B () and 2,4-fuligopyrone B () photoisomers.
该黏菌俗称“狗吐沫真菌”，在温暖潮湿的春季，会在木屑上形成鲜艳的黄色子实体（产孢组织）。2018 年，澳大利亚悉尼的理想气候条件提供了一个难得的机会，使人们能够获得大量的产孢组织，从而能够对两种avenalumamide 吡喃酮，fuligopyrone () 和 fuligopyrone B () 进行分离、纯化、结构解析和生物筛选。虽然 和 没有表现出任何明显的生物活性，但它们在 325nm 处的显著紫外吸收表明它们可能充当瞬态防晒霜，以帮助保护产孢体免受阳光照射。为了支持这一假设，将 的溶液暴露在阳光下 5 分钟，导致其与 2,4-fuligopyrone B () 和 2,4-fuligopyrone B () 光异构体的混合物迅速达到平衡。
