Köktürk Mine, Özgeriş Fatma Betül, Atamanalp Muhammed, Uçar Arzu, Özdemir Süleyman, Parlak Veysel, Duyar Hünkar Avni, Alak Gonca
Department of Organic Agriculture Management, Faculty of Applied Sciences, Igdir University, Igdir, Turkey.
Department of Nutrition and Dietetics, Faculty of Health Sciences, Ataturk University, Erzurum, Turkey.
Drug Chem Toxicol. 2024 May;47(3):296-305. doi: 10.1080/01480545.2023.2168690. Epub 2023 Jan 19.
Microplastic (MP) pollution has become a health concern subject in recent years. Althoughann increasing number of studies about the ingestion of microplastics by fish, research on the oxidative stress response to MPs in natural environments is quite limited. In this study, the identification and characterization of MPs in gill (G), muscle tissues (M), and gastrointestinal tract (GI) of turbot () were evaluated. Oxidative damage of MPs on the brain (B), liver (L), gill (G), and muscle (M) tissues as well as their effect on superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), paraoxonase (PON), arylesterase (AR) myeloperoxidase (MPO), and malondialdehyde (MDA) biomarkers were evaluated. The potential transmission of MPs from muscle tissues to humans was examined. Results showed that gills contain the highest amounts of MPs, ethylene propylene is the most dominant polymer type, black and blue are the most common MP color, fiber is the most common shape, and 50-200 µm is the most common MP size. Results showed that MPs cause oxidative stress of tissues with inhibiting effect on enzyme activities and promoting impact on lipid peroxidation. The oxidative damage mostly affected the liver (detoxification organ) followed by gill tissue. The intake of MP in the European Union was estimated by EFSA as 119 items/year, while in Turkey it is 47.88 items/year. This study shows that more research is needed in terms of ecosystem health and food chain safety. The risk assessment of MPs in living organisms and environmental matrices including food safety and human health should be considered a public health issue.
近年来，微塑料（MP）污染已成为一个备受关注的健康问题。尽管关于鱼类摄入微塑料的研究越来越多，但在自然环境中对微塑料氧化应激反应的研究却相当有限。在本研究中，对大菱鲆鳃（G）、肌肉组织（M）和胃肠道（GI）中微塑料的识别与表征进行了评估。评估了微塑料对大脑（B）、肝脏（L）、鳃（G）和肌肉（M）组织的氧化损伤及其对超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GPx）、对氧磷酶（PON）、芳基酯酶（AR）、髓过氧化物酶（MPO）和丙二醛（MDA）生物标志物的影响。研究了微塑料从肌肉组织向人类的潜在转移。结果表明，鳃中微塑料含量最高，乙丙橡胶是最主要的聚合物类型，黑色和蓝色是最常见的微塑料颜色，纤维是最常见的形状，50 - 200 µm是最常见的微塑料尺寸。结果表明，微塑料会引起组织的氧化应激，对酶活性有抑制作用，对脂质过氧化有促进作用。氧化损伤主要影响肝脏（解毒器官），其次是鳃组织。欧洲食品安全局（EFSA）估计欧盟每年微塑料摄入量为119个单位，而在土耳其为每年47.88个单位。这项研究表明，在生态系统健康和食物链安全方面还需要更多研究。对包括食品安全和人类健康在内的生物体和环境基质中微塑料的风险评估应被视为一个公共卫生问题。
