Department of Oral Medicine and Radiology, School of Dental Sciences, Krishna Institute of Medical Sciences (KIMSDU), Karad, Satara, Maharashtra, India.
Department of Pathology, School of Dental Sciences, Krishna Institute of Medical Sciences (KIMSDU), Karad, Satara, Maharashtra, India.
Indian J Dent Res. 2022 Jul-Sep;33(3):272-276. doi: 10.4103/ijdr.ijdr_551_21.
Oral submucous fibrosis (OSMF) is a potentially malignant disorder (PMD) known to transform into oral cancer. One of the important hallmarks of malignant transformation is the uncontrolled growth rate, commonly reflected as increased cell proliferation which can be significantly detected by proliferative markers such as a high Ki-67 index.
The aim of this study is to evaluate the degree and pattern of expression of Ki67 in OSMF, oral squamous cell carcinoma (OSCC) and in normal mucosal (NOM) patients and to correlate the Ki67 expression with clinical and histological grading of OSMF and OSCC patient.
A prospective cross-sectional study was conducted over a duration of two years. An immunohistochemical study was performed for Ki76 expression on 35 cases of OSMF, 10 cases of OSCC and 10 normal mucosal patients.
Data were analysed using SPSS version 21. Chi-squared test was used to analyse the differences between the intensity levels in OSMF, OSCC and NOM.
Expression of Ki67 was significantly higher in OSMF than that of NOM samples but less than that of OSCC samples. Expression of Ki67 increased with increasing grade of clinical and histological stages.
The study demonstrated a high incidence of Ki67 overexpression in OSMF and OSCC and showed a correlation between clinical and histological grading of OSMF and OSCC. Identification of high-risk oral PMDs and intervention at premalignant stages could constitute one of the key steps in reducing the mortality, morbidity and cost of treatment associated with malignant transformation of these diseases.
口腔黏膜下纤维性变（OSMF）是一种已知可转化为口腔癌的潜在恶性疾病（PMD）。恶性转化的一个重要标志是不受控制的生长速度，通常表现为细胞增殖增加，这可以通过增殖标志物如高 Ki-67 指数显著检测到。
本研究旨在评估 Ki67 在 OSMF、口腔鳞状细胞癌（OSCC）和正常黏膜（NOM）患者中的表达程度和模式，并将 Ki67 表达与 OSMF 和 OSCC 患者的临床和组织学分级相关联。
进行了为期两年的前瞻性横断面研究。对 35 例 OSMF、10 例 OSCC 和 10 例正常黏膜患者进行了 Ki76 表达的免疫组织化学研究。
使用 SPSS 版本 21 分析数据。卡方检验用于分析 OSMF、OSCC 和 NOM 之间的强度水平差异。
Ki67 在 OSMF 中的表达明显高于 NOM 样本，但低于 OSCC 样本。Ki67 的表达随着临床和组织学阶段的增加而增加。
该研究表明 OSMF 和 OSCC 中 Ki67 过度表达的发生率较高，并显示 OSMF 和 OSCC 的临床和组织学分级之间存在相关性。识别高危口腔 PMD 并在癌前阶段进行干预可能是降低这些疾病恶性转化相关死亡率、发病率和治疗成本的关键步骤之一。
