Department of Obstetrics and Gynecology, PLA Rocket Force Characteristic Medical Center, Xinjiekou Outer Street 16#, Xicheng District, Beijing, 100088, China.
Department of Quality Management, PLA Rocket Force Characteristic Medical Center, Xinjiekou Outer Street 16#, Xicheng District, Beijing, 100088, China.
Arch Gynecol Obstet. 2023 Oct;308(4):1047-1056. doi: 10.1007/s00404-022-06862-0. Epub 2023 Jan 19.
The aim of this NMA is to comprehensively analyze evidence of oral GnRH antagonist in the treatment of moderate-to-severe endometriosis-associated pain.
Literature searching was performed to select eligible studies published prior to April 2022 in PubMed, Cochrane, Embase and Web of Science. Randomized controlled trials involving patients who suffered from moderate-to-severe endometriosis-associated pain and treated with oral nonpeptide GnRH antagonists or placebo were included.
Elagolix 400 mg and ASP1707 15 mg were most efficient in reducing pelvic pain, dysmenorrhea and dyspareunia. Relugolix 40 mg was best in reducing the analgesics use. The rates of any TEAEs and TEAEs-related discontinuation were highest in relugolix 40 mg and elagolix 250 mg, respectively, while rates of hot flush and headache were highest in relugolix 40 mg and elagolix 150 mg. Significantly decreased spinal BMD was observed in elagolix 250 mg.
Oral GnRH antagonists were effective in endometriosis-associated pain in 12w, and most of the efficiency and safety outcomes were expressed in a dose-dependent manner, but linzagolix 75 mg was an exception.
本 NMA 旨在全面分析口服 GnRH 拮抗剂治疗中重度子宫内膜异位症相关疼痛的证据。
检索 PubMed、Cochrane、Embase 和 Web of Science 数据库，筛选出截至 2022 年 4 月发表的关于口服非肽 GnRH 拮抗剂治疗中重度子宫内膜异位症相关疼痛的随机对照试验。
Elagolix 400mg 和 ASP1707 15mg 最能有效减轻盆腔疼痛、痛经和性交痛。Relugolix 40mg 最能减少镇痛药的使用。任何不良事件和因不良事件而停药的发生率在 relugolix 40mg 和 elagolix 250mg 中最高，而热潮红和头痛的发生率在 relugolix 40mg 和 elagolix 150mg 中最高。Elagolix 250mg 显著降低了脊柱 BMD。
口服 GnRH 拮抗剂在 12 周时对子宫内膜异位症相关疼痛有效，大多数疗效和安全性结果呈剂量依赖性，但林扎戈利克斯 75mg 是个例外。
Zotero 插件
