From University College London and Great Ormond Street Institute of Child Health, London, United Kingdom.
the Department of Paediatric Hepatology, King's College Hospital, London, United Kingdom.
J Pediatr Gastroenterol Nutr. 2023 Apr 1;76(4):424-427. doi: 10.1097/MPG.0000000000003706. Epub 2023 Jan 19.
The aim of this study was to assess whether there has been a change in presentations of biliary atresia (BA) in England and Wales during the first and second coronavirus disease 2019 (COVID-19) lockdowns (January-June 2020 and 2021).
This population study assessed all confirmed cases of BA, from January 2020 to December 2021 across the 3 UK pediatric liver centers originating from England and Wales. Data was then compared to the incidence of confirmed BA cases from January to December 2017, 2018, and 2019.
During January-June 2020 and 2021, there were only 8 and 12 presenting cases of BA in England and Wales, compared to 16, 13, and 18 for the same time periods in 2017, 2018, and 2019, respectively. This difference was significant in a two-sided t test for 2020 ( P = 0.035) but not for 2021 ( P = 0.385). There was no difference in the mean days to Kasai procedure in January-June 2020 and 2021 compared to 2017-2019; however average time to Kasai after the lockdown periods was significantly higher.
There was a significant reduction in the presenting cases of BA during the first COVID-19 lockdown, with an increased time for BA referrals after the pandemic lockdowns were lifted in England and Wales.
本研究旨在评估在英格兰和威尔士的第一波和第二波 2019 年冠状病毒病（COVID-19）封锁期间（2020 年 1 月至 6 月和 2021 年），胆道闭锁（BA）的表现是否发生了变化。
本人群研究评估了来自英格兰和威尔士的 3 个英国儿科肝脏中心的所有确诊 BA 病例，时间范围为 2020 年 1 月至 2021 年 12 月。然后将数据与 2017 年、2018 年和 2019 年 1 月至 12 月确诊 BA 病例的发生率进行比较。
在 2020 年 1 月至 6 月和 2021 年期间，英格兰和威尔士仅有 8 例和 12 例 BA 初诊病例，而在 2017 年、2018 年和 2019 年同期分别为 16 例、13 例和 18 例。这在 2020 年的双侧 t 检验中差异显著（P=0.035），但在 2021 年不显著（P=0.385）。与 2017-2019 年相比，2020 年和 2021 年 1 月至 6 月行葛西手术的平均时间无差异；然而，封锁期后行葛西手术的平均时间明显更长。
在第一次 COVID-19 封锁期间，BA 的初诊病例明显减少，在英格兰和威尔士的大流行封锁解除后，BA 的转介时间延长。
