路的尽头：星形胶质细胞终足调节少突胶质前体细胞迁移和髓鞘形成。
End of the road: Astrocyte endfeet regulate OPC migration and myelination.
作者信息
Duncan Greg J, Emery Ben
机构信息
Jungers Center for Neurosciences Research, Department of Neurology, Oregon Health & Science University, Portland, OR 97239, USA.
出版信息
Neuron. 2023 Jan 18;111(2):139-141. doi: 10.1016/j.neuron.2022.12.023.
PMID:36657394
Abstract
Oligodendrocyte precursor cells (OPCs) use the vasculature as a scaffold for their migration. In this issue of Neuron, Su et al. determine that astrocytic ensheathment of the vasculature mediates OPC detachment from blood vessels via the secretion of semaphorins, regulating the timing of oligodendrocyte differentiation.
摘要
少突胶质前体细胞（OPCs）利用脉管系统作为其迁移的支架。在本期《神经元》杂志中，苏等人确定，脉管系统的星形胶质细胞包被通过分泌信号素介导OPCs从血管上脱离，从而调节少突胶质细胞分化的时间。
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