Burchfiel J L, Duchowny M S, Duffy F H
Science. 1979 Jun 8;204(4397):1096-8. doi: 10.1126/science.36660.
Kindling is an experimental model of epilepsy in which periodic brain stimulation induces the progressive development of electrical and behavioral seizures. A kindling-induced electrical seizure (afterdischarge) in the rat hippocampus produces prolonged neuronal supersensitivity to microiontophoretically applied acetylcholine after a latency of 40 to 60 minutes. Neuronal acetylcholine supersensitivity is correlated with the further progression of kindling. A larger hippocampal after-discharge is elicited by a subsequent kindling stimulus delivered in the presence of acetylcholine supersensitivity, but not by one delivered before the onset of the supersensitivity. The results suggest that alteration of synaptic sensitivity to acetylcholine may contribute to kindling and epileptogenesis.
点燃效应是一种癫痫实验模型，其中周期性脑刺激可诱导电活动和行为性癫痫发作的逐步发展。大鼠海马体中由点燃效应诱发的电癫痫发作（后放电）在40至60分钟的潜伏期后，会使神经元对微量离子电泳施加的乙酰胆碱产生长时间的超敏反应。神经元乙酰胆碱超敏反应与点燃效应的进一步发展相关。在存在乙酰胆碱超敏反应的情况下传递的后续点燃刺激会引发更大的海马体后放电，但在超敏反应开始前传递的刺激则不会。结果表明，突触对乙酰胆碱敏感性的改变可能有助于点燃效应和癫痫发生。
