贲门失弛缓症患者神经退行性/脱髓鞘性神经疾病之间可能存在的关联。
The possible association between neurodegenerative/demyelinating neurological disorders in achalasia patients.
作者信息
Khoury Salim T, Mari Amir
机构信息
Department of Neurology, The Nazareth Hospital EMMS, Ramat Gan, Israel, Nazareth, Israel.
The Azreili Faculty of Medicine, Bar-Ilan University, Ramat Gan, Israel.
出版信息
Transl Neurosci. 2022 Dec 31;13(1):514-515. doi: 10.1515/tnsci-2022-0269. eCollection 2022 Jan 1.
The precise pathogenesis of achalasia is still unclear. Neurodegenerative and/or demyelinating disorders (NDD) appear to share some common pathophysiological pathways described in achalasia such as inflammation, autoimmune, mitochondrial dysfunction, and neurodegeneration. Jerie et al. have published on the October issue a prospective study assessing the prevalence of several NDD in achalasia patients. In this commentary, we shed some light on the possible link between achalasia and NDD as well as comment on the study by Jerie et al.
贲门失弛缓症的确切发病机制仍不清楚。神经退行性和/或脱髓鞘疾病（NDD）似乎与贲门失弛缓症中描述的一些常见病理生理途径有共同之处，如炎症、自身免疫、线粒体功能障碍和神经退行性变。Jerie等人在10月刊上发表了一项前瞻性研究，评估贲门失弛缓症患者中几种NDD的患病率。在这篇评论中，我们阐明了贲门失弛缓症与NDD之间可能的联系，并对Jerie等人的研究进行评论。
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