全身和鞘内注射吗啡对脊髓横断大鼠的镇痛作用。
Antinociceptive effect of systemic and intrathecal morphine in spinally transected rats.
作者信息
Advokat C, Burton P
机构信息
Department of Pharmacology, University of Illinois College of Medicine, Chicago 60612.
出版信息
Eur J Pharmacol. 1987 Jul 23;139(3):335-43. doi: 10.1016/0014-2999(87)90591-7.
The antinociceptive effect of morphine on the tail withdrawal reflex was examined in spinally transected rats. The efficacy of systemically administered morphine was significantly reduced within 24 h after transection, and continued to decline during the first three posttransection weeks. In contrast to the diminished effect of systemic morphine, the efficacy of intrathecal morphine was not reduced during the first three weeks after a spinal transection. These data demonstrate a significant difference in the functional effect of systemic and spinal morphine in spinally transected rats. The results indicate that the direct antinociceptive effect of morphine on the spinal cord is not reduced after spinal transection.
在脊髓横断的大鼠中检测了吗啡对甩尾反射的镇痛作用。全身给药吗啡的效力在横断后24小时内显著降低，并在横断后的前三周持续下降。与全身吗啡作用减弱相反，鞘内注射吗啡的效力在脊髓横断后的前三周并未降低。这些数据表明全身和脊髓给予吗啡在脊髓横断大鼠中的功能效应存在显著差异。结果表明，脊髓横断后吗啡对脊髓的直接镇痛作用并未降低。
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