Wang Ling-Uei, Chen Fang-Ting, Wang Jia-Kang, Huang Tzu-Lun, Chang Pei-Yao, Chen Yun-Ju, Hsu Yung-Ray
Department of Ophthalmology, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.
Taiwan J Ophthalmol. 2022 Aug 1;12(4):465-471. doi: 10.4103/2211-5056.353129. eCollection 2022 Oct-Dec.
As a continuing demand for booster shots against SARS-CoV-2, ocular adverse events following the coronavirus disease-2019 (COVID-19) vaccines can cause significant visual impairment, and they warrant a high awareness and detailed documentation of possible ocular inflammatory manifestations. We present a case series of 11 patients presenting with ocular manifestations relevant to vaccine-associated autoimmune response within 6 weeks after the vaccination of the Oxford-AstraZeneca, the Moderna, and Pfizer-BioNTech vaccines at the main tertiary referral center in the most populated and most vaccinated city in Taiwan. Their diagnosis included five acute anterior uveitis, two multiple evanescent white dot syndrome, one probable Vogt-Koyanagi-Harada disease, one anterior scleritis, one relapsed idiopathic panuveitis, and one autoantibody-related central retinal artery occlusion. This report presented a broad spectrum of the ocular inflammatory events following the vaccination of COVID-19. Early recognition of the clinical manifestations mentioned herein with prompt management is crucial in recovering the patients' vision.
由于对严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）加强针的持续需求，2019冠状病毒病（COVID-19）疫苗接种后的眼部不良事件可导致严重视力损害，因此需要高度警惕并详细记录可能出现的眼部炎症表现。我们报告了一系列病例，共11例患者，在台湾人口最多、疫苗接种率最高的城市的主要三级转诊中心，接种牛津-阿斯利康、莫德纳和辉瑞-生物科技疫苗后6周内出现了与疫苗相关的自身免疫反应相关的眼部表现。他们的诊断包括5例急性前葡萄膜炎、2例多发性一过性白点综合征、1例可能的伏格特-小柳-原田病、1例前巩膜炎、1例复发性特发性全葡萄膜炎和1例自身抗体相关的视网膜中央动脉阻塞。本报告展示了COVID-19疫苗接种后广泛的眼部炎症事件。早期识别本文所述的临床表现并及时处理对于恢复患者视力至关重要。
