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一名学龄前女童的胫骨远端球孢子菌病性骨髓炎:病例报告

Coccidioidomycosis Osteomyelitis of Distal Tibia in a Preschool Girl: A Case Report.

作者信息

Ramírez Zamora José Arturo, Delgadillo Vargas José Abraham, Medina González Roberto, Hayakawa Dávila Victor Carlos, Acevedo Rodarte Angélica Yanawi, Arellano Pérez Vertti Rubén Daniel

机构信息

Department of Orthopaedic Surgery, Universidad Autónoma de Coahuila, Facultad de Medicina Torreón, Torreón, Coahuila, Mexico.

Department of Plastic and Reconstructive Surgery, Hospital Angeles Torreon, Torreón, Coahuila, Mexico.

出版信息

J Orthop Case Rep. 2022;12(5):66-69. doi: 10.13107/jocr.2022.v12.i05.2820.

Abstract

INTRODUCTION

Coccidioides immitis is a fungus that develops in endemic areas characterized by dry climates, with little rainfall and easy aerial dissemination. The most common form of infection is pulmonary coccidioidomycosis, although it is often asymptomatic. There are non-respiratory forms of this disease. Osteomyelitis is an extrapulmonary manifestation of C. immitis infection. Symptoms are usually nonspecific and radiographic findings are often confused with bone tumors. Treatment of coccidioidal osteomyelitis is often challenging.

CASE PRESENTATION

We report a case of a 3-year-old preschool girl from an endemic area for coccidioidomycosis who presented with pain and swelling on her left ankle. Initially, antibiotic treatment is administered for a suspected insect bite. However, her symptoms worsened and X-rays showed a lytic-like lesión. She was admitted to the hospital for biopsy and drainage surgery. The histopathological study confirms coccidioidomycosis osteomyelitis. She was started on long-term anti-fungal treatment. At 6-month follow-up, symptoms and signs of infection have been solved and X-ray image shows evidence of bone healing.

CONCLUSION

It is important to take into account aspects related to exposure to this fungus, such as the patient's place of residence and recent trips so that the diagnostic and therapeutic approach is appropriate. Coccidioidal osteomyelitis is an infrequent pathology, especially in patients without other comorbidities. Treatment is complex and often requires not only antifungal drugs but also surgical debridement.

摘要

引言

粗球孢子菌是一种在以干燥气候为特征的流行地区生长的真菌,降雨少且易于空气传播。最常见的感染形式是肺球孢子菌病,尽管通常无症状。这种疾病也有非呼吸道形式。骨髓炎是粗球孢子菌感染的肺外表现。症状通常不具特异性,影像学表现常与骨肿瘤混淆。球孢子菌性骨髓炎的治疗往往具有挑战性。

病例报告

我们报告一例来自球孢子菌病流行地区的3岁学龄前女童,她出现了左脚踝疼痛和肿胀。最初,因怀疑昆虫叮咬给予抗生素治疗。然而,她的症状恶化,X线显示有溶骨性病变。她因活检和引流手术入院。组织病理学研究证实为球孢子菌性骨髓炎。她开始接受长期抗真菌治疗。在6个月的随访中,感染的症状和体征已消失,X线影像显示有骨愈合迹象。

结论

考虑与接触这种真菌相关的因素很重要,如患者的居住地和近期旅行情况,以便采取适当的诊断和治疗方法。球孢子菌性骨髓炎是一种罕见的病症,尤其是在没有其他合并症的患者中。治疗复杂,通常不仅需要抗真菌药物,还需要手术清创。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f68f/9826543/dd95d11568c4/JOCR-12-66-g001.jpg

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