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侵袭性自然杀伤细胞白血病 1 例

A case of aggressive natural killer cell leukemia.

机构信息

Canterbury District Health Board, Christchurch, New Zealand.

Waikato District Health Board, Hamilton, New Zealand.

出版信息

Digit J Ophthalmol. 2022 Oct 29;28(4):116-118. doi: 10.5693/djo.02.2022.03.001. eCollection 2022.

DOI:10.5693/djo.02.2022.03.001
PMID:36660183
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9838178/
Abstract

A 23-year-old man presented with a 1-month history of a red and painful right eye, with visual acuity reduced to hand motions. Examination showed uveitis with keratic precipitates, cells and flare in the anterior chamber, and vitritis that obscured visualization of the right fundus. The following week, he was noted to have the following left-sided findings: reduced visual acuity (6/18), painless upper eyelid edema, an elevated, pink bulbar conjunctival lesion, limitation of ocular abduction, paresthesia in the V1 and reduced sensation in the V2 distributions. Blood tests showed pancytopenia. Results from the aspirate and trephine biopsy of his bone marrow were consistent with aggressive natural killer (NK) cell leukemia, a rare cause of ocular and periocular inflammation that requires a multidisciplinary team approach to care.

摘要

一位 23 岁男性因右眼红肿疼痛 1 个月就诊,视力下降至手动。检查发现前房有虹膜睫状体炎、角膜后沉着物、细胞和炎症,右眼眼底无法看清。一周后,他出现左眼如下表现:视力下降(6/18)、无痛性上眼睑水肿、隆起的粉红色球结膜病变、眼球外展受限、V1 区感觉异常和 V2 区感觉减退。血液检查显示全血细胞减少。骨髓抽吸和环钻活检结果符合侵袭性自然杀伤(NK)细胞白血病,这是一种罕见的眼部和眼眶炎症病因,需要多学科团队来治疗。

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本文引用的文献

1
Aggressive NK-Cell Leukemia.侵袭性自然杀伤细胞白血病
Front Pediatr. 2018 Oct 10;6:292. doi: 10.3389/fped.2018.00292. eCollection 2018.
2
CD56-Negative Aggressive NK Cell Leukemia Relapsing as Multiple Cranial Nerve Palsies: Case Report and Literature Review.以多发性颅神经麻痹形式复发的CD56阴性侵袭性自然杀伤细胞白血病:病例报告及文献复习
Case Rep Hematol. 2017;2017:3724017. doi: 10.1155/2017/3724017. Epub 2017 Oct 15.
3
Aggressive natural killer-cell leukemia: classical presentation of a rare disease.侵袭性自然杀伤细胞白血病:一种罕见疾病的典型表现。
Indian J Pathol Microbiol. 2014 Jul-Sep;57(3):483-5. doi: 10.4103/0377-4929.138787.
4
Treatment of Aggressive NK-Cell Leukemia: A Case Report and Review of the Literature.侵袭性自然杀伤细胞白血病的治疗:一例报告及文献综述
Case Rep Hematol. 2011;2011:818469. doi: 10.1155/2011/818469. Epub 2011 Nov 21.
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Ophthalmic manifestations of acute leukaemias: the ophthalmologist's role.急性白血病的眼部表现:眼科医生的作用。
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