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[3-(2-芳基-5R-苯并咪唑-1-基)丁酸的合成及其利胆活性]

[Synthesis and choleretic activity of 3-(2-aryl-5R-benzimidazol-1-yl) butanoic acids].

作者信息

Grella G, Paglietti G, Sparatore F, Manca P, Satta M

机构信息

Istituto di Chimica Farmaceutica e Tossicologica, Università di Sassari.

出版信息

Farmaco Sci. 1987 Jul;42(7):475-90.

PMID:3666121
Abstract

Thirty 3-(2-aryl-5R-benzimidazol-1-yl)butanoic acids were prepared in order to evaluate substitution effects on the 2 and 5 positions of the heterocyclic ring upon the previously recorded choleretic activity of 3-(2-phenylbenzimidazol-1-yl)butanoic acid. A general choleretic activity is shown by the acids tested, which in several cases it is superior to that of the model compound and sometimes also to that of dehydrocholic acid.

摘要

制备了30种3-(2-芳基-5R-苯并咪唑-1-基)丁酸，以评估杂环2位和5位的取代对先前记录的3-(2-苯基苯并咪唑-1-基)丁酸利胆活性的影响。所测试的酸显示出一般的利胆活性，在几种情况下，其活性优于模型化合物，有时也优于去氢胆酸。

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Farmaco Sci. 1987 Jul;42(7):475-90.
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