Toma S, Giacchero A, Bonelli L, Graziani A, De Lorenzi R, Aste H
Istituto Nazionale per, la Ricerca sul Cancro, Genova, Italy.
Eur J Surg Oncol. 1987 Oct;13(5):429-32.
The frequency of adenomatous polyps and adenocarcinomas of the large bowel in 95 patients mastectomized for breast cancer, and the prevalence of breast cancer in 77 women previously operated on for colorectal cancer were evaluated by means of a case-control study. The mastectomized patients as well as the control group, underwent a left-sided colonoscopy. The latter had been selected among women spontaneously referring to our gastroenterological out-patients clinic. The choice of this self selected control group could produce a under-estimation of the relative for colon cancer in mastectomized patients. Among mastectomized patients the frequency of adenomatous polyps and colorectal cancer was 10.5% and 5.3% respectively; while the control group showed 8.5% frequency for adenomatous polyps and 3.9% frequency for cancer. These figures are not statistically different. Patients operated on for colorectal cancer and the control group underwent clinical and mammographic examination. The prevalence of breast cancer among colorectal cancer patients and the control group women was 5.2% and 0.3% respectively (10 times higher): the difference was statistically significant (P less than 0.006). In spite of the relatively small number of studied cases, our finding are consistent with the hypothesis of a correlation between breast cancer and colorectal cancer.
通过病例对照研究，评估了95例因乳腺癌接受乳房切除术的患者大肠腺瘤性息肉和腺癌的发生率，以及77例先前接受过结肠直肠癌手术的女性乳腺癌的患病率。接受乳房切除术的患者以及对照组均接受了左侧结肠镜检查。对照组是从自发到我们胃肠病门诊就诊的女性中挑选出来的。选择这个自我选择的对照组可能会低估接受乳房切除术患者患结肠癌的相对风险。在接受乳房切除术的患者中，腺瘤性息肉和结肠直肠癌的发生率分别为10.5%和5.3%；而对照组腺瘤性息肉的发生率为8.5%，癌症发生率为3.9%。这些数字在统计学上没有差异。接受结肠直肠癌手术的患者和对照组接受了临床和乳房X线检查。结肠直肠癌患者和对照组女性中乳腺癌的患病率分别为5.2%和0.3%（前者是后者的10倍）：差异具有统计学意义（P小于0.006）。尽管研究的病例数量相对较少，但我们的发现与乳腺癌和结肠直肠癌之间存在相关性的假设是一致的。
