Lolova I, Petkov V V, Vaglenova J
Institute of Physiology, Bulgarian Academy of Sciences, Sofia.
Folia Histochem Cytobiol. 1987;25(2):119-27.
Histochemical studies were made of the activity of oxidative and hydrolytic enzymes in rat amygdala in FAS (Foetal Alcohol Syndrome). Ethanol in a dose of 9 g/kg/day was administered to rats during pregnancy and lactation in 6% aqueous solution as the only available liquid. The control rats received an equivalent diet in which ethanol was substituted by an equicaloric amount of sucrose. The offsprings were examined at the end of the 6th postnatal week. The activity of the lysosome and membrane enzymes, as well of some enzymes participating in the neurotransmission, was changed. A different decrease of the activity of oxidoreductases of Krebs cycle, glycolysis and pentose cycle was observed. The changes in the enzyme activity in the amygdala in FAS suggest alterations in the metabolism of the nervous tissue, rather than structural damages of cell organelles.
对胎儿酒精综合征（FAS）大鼠杏仁核中的氧化酶和水解酶活性进行了组织化学研究。在妊娠和哺乳期，以6%水溶液的形式，按9克/千克/天的剂量给大鼠喂食乙醇，作为唯一可获得的液体。对照大鼠接受等量饮食，其中乙醇被等量热量的蔗糖替代。在出生后第6周结束时检查后代。溶酶体酶、膜酶以及一些参与神经传递的酶的活性发生了变化。观察到三羧酸循环、糖酵解和戊糖循环的氧化还原酶活性有不同程度的降低。FAS大鼠杏仁核中酶活性的变化表明神经组织代谢发生了改变，而非细胞器的结构损伤。
