对吗啡对心脏交感神经反应影响的耐受性发展。

Development of tolerance to effects of morphine on cardiac sympathetic response.

Mantelli L, Corti V, Ledda F

Department of Pharmacology, University of Florence, Italy.

Gen Pharmacol. 1987;18(6):651-5. doi: 10.1016/0306-3623(87)90040-1.

Abstract

In isolated guinea-pig atria, morphine potentiated the response to sympathetic stimulation in a naloxone-insensitive, but calcium-sensitive way. The potentiating effect of morphine disappeared in the presence of desmethylimipramine; moreover morphine enhanced the dose-effect curve for exogenous noradrenaline. 2. Morphine was ineffective in guinea-pig atria obtained from animals implanted with morphine pellets for 4 days; on the other hand DADLE and dynorphin-(1-13) maintained their usual inhibitory effect on cardiac sympathetic response in the same kind of preparation. 3. In atria obtained from morphine-tolerant animals and maintained in vitro in the presence of morphine, removal of morphine from the bathing solution caused a new potentiating effect.

摘要

在离体豚鼠心房中，吗啡以对纳洛酮不敏感但对钙敏感的方式增强对交感神经刺激的反应。吗啡的增强作用在去甲丙咪嗪存在时消失；此外，吗啡增强了外源性去甲肾上腺素的剂量效应曲线。2. 从植入吗啡丸4天的动物获得的豚鼠心房中，吗啡无效；另一方面，DADLE和强啡肽 -（1 - 13）在同一种制剂中对心脏交感反应保持其通常的抑制作用。3. 在从吗啡耐受动物获得并在吗啡存在下体外维持的心房中，从浴液中去除吗啡会产生新的增强作用。