Castro O, Rana S R, Bang K M, Scott R B
Center for Sickle Cell Disease, Howard University College of Medicine, Washington, D.C. 20059.
Genet Epidemiol. 1987;4(4):307-11. doi: 10.1002/gepi.1370040409.
We performed hemoglobin electrophoresis in 30,400 apparently healthy black individuals in the Washington D.C. Metropolitan area, who were participating in a community based sickle-cell screening program during the period 1978-1985. The overall prevalence of sickle-cell trait was 6.7%. The frequency of sickle-cell trait in various age groups, which included young children, adults, and individuals over 65 years of age, ranged from 6.4 to 7.4%. There were no statistically significant differences in the prevalence of sickle-cell trait among the various age groups, nor did we detect a significant trend for increasing or decreasing sickle cell frequency with advancing age (P = 0.418). Thus, in this population sickle-cell trait appears to have no effect on longevity. If the various complications of sickle-cell trait reported in the literature are not fortuitous, their frequency and/or severity must be too low to affect prevalence figures.
1978年至1985年期间，我们对华盛顿特区大都会区30400名表面健康的黑人个体进行了血红蛋白电泳，这些个体参与了一项基于社区的镰状细胞筛查项目。镰状细胞性状的总体患病率为6.7%。不同年龄组（包括幼儿、成年人和65岁以上个体）的镰状细胞性状频率在6.4%至7.4%之间。不同年龄组之间镰状细胞性状的患病率没有统计学上的显著差异，我们也未检测到随着年龄增长镰状细胞频率增加或减少的显著趋势（P = 0.418）。因此，在这个人群中，镰状细胞性状似乎对寿命没有影响。如果文献中报道的镰状细胞性状的各种并发症不是偶然的，那么它们的频率和/或严重程度肯定太低，以至于不会影响患病率数据。
