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美洲水貂免疫球蛋白的免疫遗传学。VI. Cγ-同种异型H2、H3和H4偏离孟德尔分离规律

[Immunogenetics of immunoglobulins of the American mink. VI. Deviation from Mendelian segregation for Cgamma-allotypes H2, H3 and H4].

作者信息

Fomicheva I I, Baranov O K

出版信息

Genetika. 1987 Aug;23(8):1491-8.

PMID:3666449
Abstract

The non-expression of parental allotype among mink F1 offsprings of monohybrid analyzing crosses was established for C gamma-allotypes. A phenotype ratio 0:1, instead of the expected Mendelian 1:1, was observed in some families. The non-expression of allotype may occur in the progeny of mink with normal allotypic specificity. Deviations of allotypic expression had both qualitative and quantitative nature and did not depend on the direction of crossings. Sometimes, the appearance of allotype in a mink could not be expected on the basis of its pedigree. Instability of expression and inheritance of H2, H3 and H4 in many families may have masked the allelic or linkage relationships of these genetic markers.

摘要

在单杂交分析杂交的水貂F1后代中,已确定Cγ同种异型不存在亲本同种异型的表达。在一些家族中观察到表型比例为0:1,而非预期的孟德尔式1:1。同种异型不表达可能发生在具有正常同种异型特异性的水貂后代中。同种异型表达的偏差具有定性和定量性质,且不依赖于杂交方向。有时,根据水貂的谱系无法预期其同种异型的出现。许多家族中H2、H3和H4表达与遗传的不稳定性可能掩盖了这些遗传标记的等位基因或连锁关系。

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