Delville Y, Balthazart J
Laboratory of General and Comparative Biochemistry, University of Liège, Belgium.
Horm Behav. 1987 Sep;21(3):288-309. doi: 10.1016/0018-506x(87)90016-x.
Four experiments were carried out to study the hormonal control of female receptivity and proceptivity in Japanese quail. Both aspects of reproductive behavior can be activated in a dose-dependent manner by injections of estradiol benzoate (EB). Progesterone (P) given in addition to suboptimal doses of EB has little additional stimulatory effect. Other aspects of the reproductive physiology such as enlargement of the cloacal diameter and growth of the oviduct also seem to be controlled primarily by estrogens with little or no additive effect of P. These conclusions were confirmed by injecting egg-laying females with an antiestrogen, tamoxifen, or an antiprogestin, RU38486. Only the former had marked effects on sexual receptivity, cloacal diameter, and oviduct weight. The inhibiting effects of tamoxifen could easily be reversed by injecting females with large doses of estrogen, which demonstrates that tamoxifen acts on an estrogen-dependent mechanism and not through nonspecific effects.
进行了四项实验来研究日本鹌鹑雌性接受性和主动求偶行为的激素控制。通过注射苯甲酸雌二醇（EB），生殖行为的这两个方面都可以以剂量依赖的方式被激活。除了给予次优剂量的EB外再给予孕酮（P）几乎没有额外的刺激作用。生殖生理学的其他方面，如泄殖腔直径的增大和输卵管的生长，似乎也主要由雌激素控制，P几乎没有或没有附加作用。给产蛋雌性注射抗雌激素他莫昔芬或抗孕激素RU38486证实了这些结论。只有前者对性接受性、泄殖腔直径和输卵管重量有显著影响。通过给雌性注射大剂量雌激素可以很容易地逆转他莫昔芬的抑制作用，这表明他莫昔芬作用于雌激素依赖性机制，而不是通过非特异性作用。
