Instituto Colombiano de Medicina Tropical-Universidad CES, Medellín, Colombia.
Grupo de Investigación en Ciencias de la Educación y de la Salud (ICES), UNISANGIL, San Gil, Colombia; and.
Am J Dermatopathol. 2023 Feb 1;45(2):99-106. doi: 10.1097/DAD.0000000000002335. Epub 2022 Dec 7.
Leprosy is an ancient and chronic infectious disease caused by 2 mycobacteria (Mycobacterium leprae and Mycobacterium lepromatosis). Recently, our research group observed that HES-1, an innate cellular component of the Notch signaling pathway, is related to the pathogenesis of leprosy. Therefore, it could be helpful in its detection.
To determine the expression of HES-1 in the skin of patients with paucibacillary (PB) leprosy.
A cross-sectional, descriptive, observational study was conducted. Forty-five skin samples from patients with leprosy were evaluated (30 samples from MB leprosy and 15 from PB leprosy) using immunohistochemistry of HES-1 and S-100.
PB leprosy biopsies revealed a reduction of HES-1 in 66.7% of the epidermis, 80% of the eccrine glands, and 62.5% of the hair follicles of these patients, with statistical differences in the control group (P < 0.0001). Besides, HES-1 showed similar utility to S-100 immunostaining in detecting the MB and PB leprosy.
HES-1 is a transcriptional factor also reduced in PB patients' epidermis and skin appendages. Finally, our data show that HES-1 could be a biomarker in diagnosing PB and MB leprosy.
麻风病是一种由两种分枝杆菌（麻风分枝杆菌和麻风分枝杆菌）引起的古老的慢性传染病。最近，我们的研究小组观察到 Notch 信号通路的固有细胞成分 HES-1 与麻风病的发病机制有关。因此，它可能有助于对麻风病的检测。
确定 HES-1 在少菌型麻风病患者皮肤中的表达。
进行了一项横断面、描述性、观察性研究。评估了 45 例麻风病患者的皮肤样本（30 例来自 MB 麻风病，15 例来自 PB 麻风病），使用 HES-1 和 S-100 的免疫组织化学。
PB 麻风病活检显示 66.7%的表皮、80%的外分泌腺和 62.5%的患者毛囊中的 HES-1 减少，与对照组有统计学差异（P<0.0001）。此外，HES-1 在检测 MB 和 PB 麻风病方面与 S-100 免疫染色具有相似的效用。
HES-1 是一种转录因子，也减少了 PB 患者的表皮和皮肤附属物。最后，我们的数据表明 HES-1 可能是诊断 PB 和 MB 麻风病的生物标志物。
