Department of Psychiatry, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Nagano, Japan.
Department of Radiology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Nagano, Japan.
Psychiatry Res Neuroimaging. 2023 Mar;329:111596. doi: 10.1016/j.pscychresns.2023.111596. Epub 2023 Jan 16.
Pathophysiological difference of depression in patients with and without autistic spectrum disorder (ASD) has not been investigated previously. Therefore, we sought to determine whether there were differences between non-ASD and ASD groups on resting-state functional magnetic resonance imaging (rs-fMRI) in patients with depression. We performed 3T MRI under resting state in 8 patients with depression and ASD and 12 patients with depression but without ASD. The ASD group showed increased functional connectivity in the cerebellar network of the left posterior inferior temporal gyrus and anterior cerebellar lobes compared to the non-ASD group in an analysis of covariance. Adding antipsychotics, antidepressants, benzodiazepines, nonbenzodiazepines, anxiolytics, hypnotics, or age as covariates showed a similar increase in functional connectivity. Thus, this study found that depressive patients with ASD had increased functional connectivity in the cerebellar network. Our findings suggest that fMRI may be able to evaluate differences in depressed patients with and without ASD.
先前尚未研究伴有和不伴有自闭症谱系障碍（ASD）的抑郁症患者的病理生理学差异。因此，我们旨在确定在抑郁症患者的静息状态功能磁共振成像（rs-fMRI）中，非 ASD 组和 ASD 组之间是否存在差异。我们在 8 名伴有 ASD 的抑郁症患者和 12 名不伴有 ASD 的抑郁症患者中进行了 3T MRI 检查。在协方差分析中，与非 ASD 组相比，ASD 组的左后下颞叶和前小脑叶小脑网络的功能连接增加。添加抗精神病药、抗抑郁药、苯二氮䓬类、非苯二氮䓬类、抗焦虑药、催眠药或年龄作为协变量，显示功能连接增加相似。因此，本研究发现伴有 ASD 的抑郁症患者的小脑网络功能连接增加。我们的研究结果表明，fMRI 可能能够评估伴有和不伴有 ASD 的抑郁症患者的差异。
