Department of Neurology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, P.R. China.
Department of Neurology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, P. R. China; Shandong Provincial Clinical Research Center for Neurological Diseases, Jinan, Shandong, P. R. China; Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, P. R. China.
Neurobiol Aging. 2023 May;125:109-114. doi: 10.1016/j.neurobiolaging.2023.01.003. Epub 2023 Jan 8.
We sought to examine the associations of common WWC1 variants with Alzheimer's disease (AD) and vascular dementia (VaD) among rural-dwelling older adults in China. This population-based study used data from the baseline assessments (March -September 2018) of MIND-China. AD and VaD were diagnosed following the international criteria. Of the 5455 participants (age≥60 years, 57.27% women), 182 were diagnosed with AD and 88 with VaD. Logistic regression analysis suggested that WWC1 rs17070145 C allele (vs. T) was associated with multivariable-adjusted odds ratio of 1.23 (95% confidence interval 0.96-1.58) for AD, and that CC genotype (vs. TT) was associated with multivariable-adjusted odds ratio of 2.19(1.10-4.39) for VaD, but the association with VaD became non-significant when further adjusting for stroke history. Furthermore, exonic SNPs rs3822660 and rs3822659 were in strong linkage disequilibrium (LD) with rs17070145 (D' = 0.88). These results suggest that the strong LD between rs17070145 and 2 exonic SNPs may explain the association of WWC1 rs17070145 C allele with AD and that stroke may partly explain the association of WWC1 rs17070145 CC genotype with VaD.
我们旨在研究常见 WWC1 变体与中国农村老年人群中阿尔茨海默病 (AD) 和血管性痴呆 (VaD) 的关联。这项基于人群的研究使用了 MIND-China 基线评估 (2018 年 3 月至 9 月) 的数据。AD 和 VaD 按照国际标准进行诊断。在 5455 名参与者 (年龄≥60 岁，57.27%为女性) 中，有 182 人被诊断为 AD，88 人被诊断为 VaD。逻辑回归分析表明，与 WWC1 rs17070145 的 T 等位基因相比，C 等位基因 (CC 基因型) 与多变量校正后的 AD 比值比为 1.23 (95%置信区间 0.96-1.58)，与 VaD 的比值比为 2.19(1.10-4.39)，但当进一步调整中风史后，与 VaD 的关联变得不显著。此外，外显子 SNPs rs3822660 和 rs3822659 与 rs17070145 存在强连锁不平衡 (D' = 0.88)。这些结果表明，rs17070145 与 2 个外显子 SNPs 之间的强连锁不平衡可能解释了 rs17070145 C 等位基因与 AD 的关联，而中风可能部分解释了 rs17070145 CC 基因型与 VaD 的关联。
