尿素治疗低钠血症性充血性心力衰竭的水潴留

Urea treatment for water retention in hyponatremic congestive heart failure.

作者信息

Cauchie P, Vincken W, Decaux G

机构信息

Department of Internal Medicine, University Hospital Erasme (ULB), Brussels, Belgium.

出版信息

Int J Cardiol. 1987 Oct;17(1):102-4. doi: 10.1016/0167-5273(87)90040-4.

DOI:10.1016/0167-5273(87)90040-4

PMID:3666993

Abstract

We have studied the efficiency of urea in the treatment of hyponatremia and hydrosaline retention in a 76-year-old man with chronic ischemic congestive heart failure. Since increase of furosemide worsened the hyponatremia (120 mmol/l), 30 g/day of urea was added and induced the following changes: progressive weight loss (6.5 kg in one week), increased diuresis (from 0.750 to 1.950 l/day), increased salt excretion (from 40 to 165 mmol sodium/day) and correction of the hyponatremia (120 to 136 mmol/l). Blood urea and creatinine serum concentrations rose moderately without significant change in creatinine clearance (32 to 38 ml/min). No adverse effects related to urea administration were observed. Urea intake seems to be useful in the management of hyponatremia in our patient with cardiac failure.

摘要

我们研究了尿素对一名患有慢性缺血性充血性心力衰竭的76岁男性低钠血症和水盐潴留的治疗效果。由于增加呋塞米会使低钠血症恶化（降至120 mmol/l），因此添加了每日30克尿素，随后出现了以下变化：体重逐渐减轻（一周内减轻6.5千克）、尿量增加（从每日0.750升增至1.950升）、盐排泄增加（钠从每日40 mmol增至165 mmol）以及低钠血症得到纠正（从120 mmol/l升至136 mmol/l）。血尿素和血清肌酐浓度适度升高，肌酐清除率无显著变化（从32 ml/min增至38 ml/min）。未观察到与使用尿素相关的不良反应。在我们这位心力衰竭患者中，摄入尿素似乎对低钠血症的治疗有益。