UPLC-QTOF-MS-Based Metabolomics and Antioxidant Capacity of from Different Geographical Origins.

() has been commonly utilized as a therapeutic plant in traditional medicine. In this study, we examined variations in metabolites in roots grown in different regions using ultra-high performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS). Multivariate analysis showed that the metabolite profiles of plants grown in Hoengseong and Jeongseon were more similar to each other than to that of grown in Jeju. Most primary metabolites were present at higher levels in grown in Jeju. In contrast, grown in Hoengseong and Jeongseon had high levels of secondary metabolites such as phenylpropanoids and triterpenoid saponins, respectively. In addition, the bioactive compound content and antioxidant capacity of in grown in Hoengseong and Jeongseon were observed to be higher than those of grown in Jeju. This study suggests that metabolomics is an effective approach to investigate the difference of metabolite profiling in from different geographical origins, and is useful for evaluating its pharmacological potential.