James Genevieve, Stephenson Kevin, Callaghan-Gillespie Meghan, Kamara Mohamed Tabita, Park Hui Gyu, Brenna J Thomas, Manary Mark J
Dell Pediatric Research Institute, The University of Texas at Austin, Austin, TX 78723, USA.
Department of Medicine, Washington University, St. Louis, MO 63110, USA.
Foods. 2023 Jan 9;12(2):308. doi: 10.3390/foods12020308.
Ready-to-use therapeutic food (RUTF) is used to treat young children diagnosed with severe acute malnutrition. RUTF with low and balanced linoleic and alpha-linolenic acid, plus omega-3 docosahexaenoic acid (DHA), supports long-term cognitive recovery. DHA is prone to degradation due to peroxidation, possibly exacerbated by the iron inherently in RUTF. Our goals were to prepare benchtop and manufacturing scale of RUTF formulations that include DHA and measure its retention. Twenty-seven RUTF formulas with base ingredients, including oats, high oleic or commodity peanuts, and encapsulated or oil-based DHA at various levels were prepared at benchtop scale, followed by seven months of climate-controlled storage. These pilot samples had similar relative DHA retention. At the manufacturing scale, DHA was added at one of two stages in the process, either at the initial or the final mixing stage. Samples taken at preliminary or later steps show that less than 20% of DHA added at the early stages disappeared prior to packaging for any recipe tested. Overall, our data indicate that most DHA included in RUTF is retained in the final product and that DHA is best retained when added at the latest manufacturing stage.
即用型治疗性食品（RUTF）用于治疗被诊断为患有重度急性营养不良的幼儿。富含低水平且均衡的亚油酸和α-亚麻酸，再加上ω-3二十二碳六烯酸（DHA）的RUTF有助于长期认知恢复。DHA由于过氧化作用容易降解，RUTF中固有的铁可能会加剧这种情况。我们的目标是制备包含DHA的RUTF配方的台式规模和生产规模样品，并测量其留存率。在台式规模下制备了27种含有基础成分的RUTF配方，这些基础成分包括燕麦、高油酸花生或普通花生，以及不同含量的胶囊型或油基DHA，随后在气候控制条件下储存七个月。这些试验样品具有相似的相对DHA留存率。在生产规模下，DHA在该过程的两个阶段之一添加，即在初始混合阶段或最终混合阶段。在初步或后续步骤采集的样品表明，对于所测试的任何配方，在早期添加的DHA在包装前消失的比例不到20%。总体而言，我们的数据表明，RUTF中包含的大多数DHA保留在最终产品中，并且在生产的最后阶段添加DHA时留存效果最佳。
