School of Nursing, University of Michigan, Ann Arbor, MI 48109, USA.
School of Nursing, Peking University, Beijing 100191, China.
Int J Environ Res Public Health. 2023 Jan 5;20(2):1001. doi: 10.3390/ijerph20021001.
Purpose: Physical activity (PA) plays an important role in health outcomes for people with cancer, and pre-diagnosis PA influences PA behaviors after cancer treatment. Less is known about the PA of lung cancer patients, and the strong history of smoking could influence pre-diagnosis levels of PA and place them at risk for health problems. This study aimed to compare pre-diagnosis PA and its correlates in patients with lung cancer and other types of cancer (female breast, colorectal, and prostate cancer) and examine the relationship between pre-diagnosis PA and all-cause mortality. Methods: This study used data from the UK Biobank, which is a national cohort study with accelerometry data. We included 2662 participants and used adjusted linear regressions and survival analyses. Results: Male and female lung cancer groups spent a mean of 78 and 91 min/day in pre-diagnosis moderate to vigorous PA (MVPA), respectively; this is lower than the 3 other types of cancer (p < 0.001). Younger age and faster walking pace had a strong association with PA in all the four types of cancer (p < 0.01). Smoking status had a strong association with PA in the lung cancer group, while obesity had a strong association with PA in female breast, colorectal, and prostate cancer (p < 0.01). Higher levels of pre-diagnosis MVPA (≥1.5 h/day) were associated with a significantly lower all-cause mortality risk. Conclusions: The present study suggests that lung cancer patients are the most inactive population before diagnosis. The identified difference in correlates of PA suggest that cancer-specific approaches are needed in PA research and practices. This study also highlights the importance of high PA for individuals with high cancer risk.
身体活动（PA）对癌症患者的健康结果起着重要作用，且癌症诊断前的 PA 会影响癌症治疗后的 PA 行为。人们对肺癌患者的 PA 知之甚少，而强烈的吸烟史可能会影响癌症诊断前的 PA 水平，并使他们面临健康问题的风险。本研究旨在比较肺癌患者与其他类型癌症（女性乳腺癌、结直肠癌和前列腺癌）患者的癌症诊断前 PA 及其相关因素，并探讨癌症诊断前 PA 与全因死亡率之间的关系。
本研究使用了英国生物银行（UK Biobank）的数据，这是一项具有加速度计数据的全国队列研究。我们纳入了 2662 名参与者，并使用了调整后的线性回归和生存分析。
男性和女性肺癌组在癌症诊断前分别平均每天进行 78 和 91 分钟的中高强度 PA（MVPA）；这低于其他 3 种癌症（p < 0.001）。在所有 4 种癌症中，年龄较小和行走速度较快与 PA 呈强相关（p < 0.01）。吸烟状况与肺癌组的 PA 呈强相关，而肥胖与女性乳腺癌、结直肠癌和前列腺癌的 PA 呈强相关（p < 0.01）。较高的癌症诊断前 MVPA（≥1.5 小时/天）与全因死亡率风险显著降低相关。
本研究表明，肺癌患者在诊断前是最不活跃的人群。PA 相关因素的差异表明，PA 研究和实践需要针对特定癌症的方法。本研究还强调了高 PA 对高癌症风险个体的重要性。
