European Institute for Molecular Imaging, University of Münster, Waldeyerstr. 15, 48149 Münster, Germany.
Int J Mol Sci. 2023 Jan 10;24(2):1374. doi: 10.3390/ijms24021374.
The homotrimeric P2X7 receptor (P2X7R) is expressed by virtually all cells of the innate and adaptive immune system and plays a crucial role in various pathophysiological processes such as autoimmune and neurodegenerative diseases, inflammation, neuropathic pain and cancer. Consequently, the P2X7R is considered a promising target for therapy and diagnosis. As the development of tracers comes hand-in-hand with the development of potent and selective receptor ligands, there is a rising number of PET tracers available in preclinical and clinical studies. This review analyzes the development of P2X7R positron emission tomography (PET) tracers and their potential in various PET imaging applications.
三聚体嘌呤能 P2X7 受体 (P2X7R) 几乎表达于先天和适应性免疫系统的所有细胞中，在多种病理生理过程中发挥着关键作用，如自身免疫和神经退行性疾病、炎症、神经病理性疼痛和癌症。因此，P2X7R 被认为是一种有前途的治疗和诊断靶点。由于示踪剂的开发与有效和选择性受体配体的开发齐头并进，目前已有越来越多的 PET 示踪剂在临床前和临床研究中得到应用。本文综述了 P2X7R 正电子发射断层扫描 (PET) 示踪剂的发展及其在各种 PET 成像应用中的潜力。
