Institute of Biomedical Chemistry, 10 Bldg. 8, Pogodinskaya Str., 119121 Moscow, Russia.
Federal Budget Public Health Institution "Clinical Center of HIV/AIDS Treatment and Prevention" of the Ministry of Health of Krasnodar Region, 204/2, im. Mitrofana Sedina Str., 350000 Krasnodar, Russia.
Int J Mol Sci. 2023 Jan 11;24(2):1465. doi: 10.3390/ijms24021465.
Viruses cause various infections that may affect human lifestyle for durations ranging from several days to for many years. Although preventative and therapeutic remedies are available for many viruses, they may still have a profound impact on human life. The human immunodeficiency virus type 1 is the most common cause of HIV infection, which represents one of the most dangerous and complex diseases since it affects the immune system and causes its disruption, leading to secondary complications and negatively influencing health-related quality of life. While highly active antiretroviral therapy may decrease the viral load and the velocity of HIV infection progression, some individual peculiarities may affect viral load control or the progression of T-cell malfunction induced by HIV. Our study is aimed at the text-based identification of molecular mechanisms that may be involved in viral infection progression, using HIV as a case study. Specifically, we identified human proteins and genes which commonly occurred, overexpressed or underexpressed, in the collections of publications relevant to (i) HIV infection progression and (ii) acute and chronic stages of HIV infection. Then, we considered biological processes that are controlled by the identified protein and genes. We verified the impact of the identified molecules in the associated clinical study.
病毒可引起各种感染，这些感染可能会影响人类的生活方式，持续时间从数天到数年不等。尽管有许多预防和治疗方法可用于治疗多种病毒，但它们仍可能对人类生活产生深远影响。人类免疫缺陷病毒 1 型是导致 HIV 感染的最常见原因，HIV 是一种最危险和最复杂的疾病之一，因为它会影响免疫系统并导致其功能紊乱，从而引发继发性并发症，并对与健康相关的生活质量产生负面影响。虽然高效抗逆转录病毒疗法可以降低病毒载量和 HIV 感染进展的速度，但个体的一些特殊情况可能会影响病毒载量的控制或 HIV 引起的 T 细胞功能障碍的进展。我们的研究旨在基于文本识别可能与病毒感染进展相关的分子机制，以 HIV 作为案例研究。具体来说，我们确定了在与 (i) HIV 感染进展和 (ii) HIV 急性和慢性感染阶段相关的文献集合中经常出现、过表达或低表达的人类蛋白质和基因。然后，我们考虑了由鉴定出的蛋白质和基因控制的生物学过程。我们验证了鉴定出的分子在相关临床研究中的作用。
