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基于聚羟基丁酸酯（PHB）并经氯高铁血红素改性的电纺纤维材料的生物相容性和抗菌活性

Biocompatibility and Antimicrobial Activity of Electrospun Fibrous Materials Based on PHB and Modified with Hemin.

作者信息

Tyubaeva Polina M, Varyan Ivetta A, Nikolskaya Elena D, Mollaeva Mariia R, Yabbarov Nikita G, Sokol Maria B, Chirkina Margarita V, Popov Anatoly A

机构信息

Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 4 Kosygina Street, 119334 Moscow, Russia.

Academic Department of Innovational Materials and Technologies Chemistry, Plekhanov Russian University of Economics, 36 Stremyanny Per., 117997 Moscow, Russia.

出版信息

Nanomaterials (Basel). 2023 Jan 5;13(2):236. doi: 10.3390/nano13020236.

DOI:10.3390/nano13020236
PMID:36677989
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9861043/
Abstract

The effect of the hemin (Hmi) on the structure and properties of nanocomposite electrospun materials based on poly-3-hydroxybutyrate (PHB) is discussed in the article. The additive significantly affected the morphology of fibers allowed to produce more elastic material and provided high antimicrobial activity. The article considers also the impact of the hemin on the biocompatibility of the nonwoven material based on PHB and the prospects for wound healing.

摘要

本文讨论了氯高铁血红素（Hmi）对基于聚-3-羟基丁酸酯（PHB）的纳米复合电纺材料的结构和性能的影响。该添加剂显著影响纤维形态，使得能够制备出更具弹性的材料，并具有高抗菌活性。本文还考虑了氯高铁血红素对基于PHB的非织造材料生物相容性的影响以及伤口愈合的前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f3d/9861043/ac3c74a300f9/nanomaterials-13-00236-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f3d/9861043/42df2c5f5fb4/nanomaterials-13-00236-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f3d/9861043/019f15602263/nanomaterials-13-00236-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f3d/9861043/77de8f32d310/nanomaterials-13-00236-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f3d/9861043/30a401f5ec81/nanomaterials-13-00236-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f3d/9861043/4c58ce985c7b/nanomaterials-13-00236-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f3d/9861043/6a3734b01b3b/nanomaterials-13-00236-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f3d/9861043/2a7635a9552b/nanomaterials-13-00236-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f3d/9861043/8c5d17a44b9e/nanomaterials-13-00236-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f3d/9861043/7ee2e5178354/nanomaterials-13-00236-g009a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f3d/9861043/ac3c74a300f9/nanomaterials-13-00236-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f3d/9861043/42df2c5f5fb4/nanomaterials-13-00236-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f3d/9861043/019f15602263/nanomaterials-13-00236-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f3d/9861043/77de8f32d310/nanomaterials-13-00236-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f3d/9861043/30a401f5ec81/nanomaterials-13-00236-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f3d/9861043/4c58ce985c7b/nanomaterials-13-00236-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f3d/9861043/6a3734b01b3b/nanomaterials-13-00236-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f3d/9861043/2a7635a9552b/nanomaterials-13-00236-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f3d/9861043/8c5d17a44b9e/nanomaterials-13-00236-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f3d/9861043/7ee2e5178354/nanomaterials-13-00236-g009a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f3d/9861043/ac3c74a300f9/nanomaterials-13-00236-g010.jpg

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2
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ACS Appl Polym Mater. 2022 Sep 9;4(9):6592-6601. doi: 10.1021/acsapm.2c00967. Epub 2022 Aug 16.
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Nanomaterials (Basel). 2023 May 12;13(10):1625. doi: 10.3390/nano13101625.
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RSC Adv. 2019 Jul 25;9(40):23071-23080. doi: 10.1039/c9ra04465e. eCollection 2019 Jul 23.
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