Czarnecki C M, Ali B H
Department of Veterinary Biology, College of Veterinary Medicine, University of Minnesota, St. Paul 55108.
J Comp Pathol. 1987 Jul;97(4):407-13. doi: 10.1016/0021-9975(87)90019-3.
Furazolidone (700 ppm) was fed to turkey poults from 2 to 5 weeks of age. The drug produced a cardiomyopathy and reduced the feed intake and growth of the birds. Thiamin was concurrently injected into the furazolidone-fed poults to determine whether the vitamin would prevent or reduce the severity of the cardiotoxic effect of the drug. Supplemental injections of thiamin had no significant effect on feed consumption or growth of the birds nor did they protect the heart against the cardiotoxicity. The conclusion is that furazolidone-induced cardiomyopathy is not caused by a thiamin deficiency.
将呋喃唑酮（700 ppm）从2周龄至5周龄投喂给小火鸡。该药物引发了一种心肌病，并降低了禽类的采食量和生长速度。同时向投喂呋喃唑酮的小火鸡注射硫胺素，以确定这种维生素是否能预防或减轻该药物的心脏毒性作用的严重程度。额外注射硫胺素对禽类的采食量或生长没有显著影响，也没有保护心脏免受心脏毒性的影响。结论是，呋喃唑酮诱导的心肌病不是由硫胺素缺乏引起的。
