Department of Medicine, AIIMS, New Delhi, Delhi, India.
Department of Pathology, AIIMS, New Delhi, Delhi, India.
J R Coll Physicians Edinb. 2023 Mar;53(1):23-26. doi: 10.1177/14782715221149709. Epub 2023 Jan 20.
is a rare cause of granulomatous amoebic encephalitis (GAE) associated with high mortality. There have been few case reports of Acanthamoeba meningoencephalitis worldwide. Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory condition caused by abnormally active macrophages and cytotoxic T lymphocytes; its secondary form is due to infections or malignancies. However, HLH is rather an unknown complication of GAE. We describe an unusual and previously unreported case of Acanthamoeba meningoencephalitis in a young immunocompetent female culminating in secondary HLH.
棘阿米巴脑膜脑炎是一种罕见的肉芽肿性阿米巴脑炎（GAE）病因，死亡率较高。全球范围内棘阿米巴脑膜脑炎的病例报告较少。噬血细胞性淋巴组织细胞增生症（HLH）是由异常活跃的巨噬细胞和细胞毒性 T 淋巴细胞引起的严重炎症反应状态；其继发性是由感染或恶性肿瘤引起的。然而，HLH 是 GAE 的一种未知并发症。我们描述了一例年轻免疫功能正常女性的棘阿米巴脑膜脑炎的不常见和以前未报道的病例，最终导致继发性 HLH。
