Wang Chun, Lv Jie, Zhu Qiaoling, Zhuang Wei, Xie Ling, Liu Guangyu, Saimaier Kaidireya, Shi Changjie, Hua Qiuhong, Yue Rui, Du Changsheng
Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopaedic Department of Tongji Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
Immunobiology. 2023 Mar;228(2):152341. doi: 10.1016/j.imbio.2023.152341. Epub 2023 Jan 18.
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS), characterized by demyelinating neuropathy. Despite a long period of research on the immune mechanisms involved in CNS diseases, the etiology of MS remains unknown. MS may present with different clinical and pathological manifestations due to the involvement of different pathogenic processes, including balance and mobility disorders, psychiatric abnormalities, and intestinal dysfunction. We used an animal model of MS, experimental autoimmune encephalomyelitis (EAE), to assess clinical symptoms of MS with the aim of creating new indicators for the assessment of EAE. Our results show that EAE mice develop severe bone loss, anxiety-like moods, and intestinal inflammation in addition to clinical phenomena such as inflammatory infiltration and demyelination of the spinal cord. Our new indicators aim to provide a more comprehensive assessment of MS to avoid the pitfalls of a single intervention and also to provide a more systematic assessment of the effectiveness of drugs used to treat MS.
多发性硬化症（MS）是一种中枢神经系统（CNS）的自身免疫性疾病，其特征为脱髓鞘性神经病变。尽管对中枢神经系统疾病所涉及的免疫机制进行了长期研究，但MS的病因仍然不明。由于不同致病过程的参与，MS可能表现出不同的临床和病理表现，包括平衡和运动障碍、精神异常以及肠道功能障碍。我们使用MS的动物模型——实验性自身免疫性脑脊髓炎（EAE）来评估MS的临床症状，目的是创建评估EAE的新指标。我们的结果表明，EAE小鼠除了出现脊髓炎症浸润和脱髓鞘等临床现象外，还会出现严重的骨质流失、焦虑样情绪和肠道炎症。我们的新指标旨在对MS进行更全面的评估，以避免单一干预的缺陷，同时也为用于治疗MS的药物有效性提供更系统的评估。
