利用表观遗传靶点进行生物皮肤再生。

Biological skin regeneration using epigenetic targets.

作者信息

Mohammed Fahad Hussain, Cemic Franz, Hemberger Jürgen, Giri Shibashish

机构信息

Biomedical and Biotechnological Center (BBZ), University of Leipzig, Leipzig, Germany; Institute of Biochemical Engineering & Analysis, University of Applied Sciences, Giessen, Germany.

Institute of Biochemical Engineering & Analysis, University of Applied Sciences, Giessen, Germany.

出版信息

Drug Discov Today. 2023 Apr;28(4):103495. doi: 10.1016/j.drudis.2023.103495. Epub 2023 Jan 18.

DOI:10.1016/j.drudis.2023.103495

PMID:36681237

Abstract

Epigenetics targets are the newest branches for building a novel platform of drugs for preventive and regenerative skin health care. Epigenetic regions [vascular endothelial growth factor (VEGF), epidermal growth factor receptor (EGFR), transforming growth factor beta (TGFβ), DNA methyltransferases (DNMTs), histone deacetylase 1/2 (HDAC1/2), and miRNA) are innovative druggable targets. As we discuss here, a series of epigenetic-based small molecules are undergoing both clinical and preclinical trials for skin regeneration. Epigenetic writers, eraser targets, and epigenetic readers will become the key therapeutic windows for skin regenerative in the near future.

摘要

表观遗传学靶点是构建用于预防性和再生性皮肤保健的新型药物平台的最新分支。表观遗传区域[血管内皮生长因子（VEGF）、表皮生长因子受体（EGFR）、转化生长因子β（TGFβ）、DNA甲基转移酶（DNMTs）、组蛋白去乙酰化酶1/2（HDAC1/2）和微小RNA（miRNA）]是创新的可成药靶点。正如我们在此所讨论的，一系列基于表观遗传学的小分子正在进行皮肤再生的临床试验和临床前试验。表观遗传书写蛋白、擦除蛋白靶点和表观遗传阅读蛋白在不久的将来将成为皮肤再生的关键治疗窗口。