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θ波功率和功能连接性作为日常生活中存在认知主诉个体执行功能的神经生理学标志物。

Theta power and functional connectivity as neurophysiological markers of executive functions in individuals with cognitive complaints in daily life.

作者信息

Smit Diede, Trevino Lorena, Mohamed Saleh M H, Enriquez-Geppert Stefanie

机构信息

Department of Clinical and Developmental Neuropsychology, University of Groningen, the Netherlands; Research School of Behavioural and Cognitive Neurosciences, University of Groningen, the Netherlands.

Department of Clinical and Developmental Neuropsychology, University of Groningen, the Netherlands.

出版信息

Biol Psychol. 2023 Mar;178:108503. doi: 10.1016/j.biopsycho.2023.108503. Epub 2023 Jan 19.

Abstract

Impairments in executive functions (EFs) are common across psychological disorders. Research into the neural oscillations underlying EFs has the potential to help understand these impairments and contribute to the development of interventions. The aim of this study is to assess theta power and functional theta connectivity in the sensor space of the regions of the superordinate network for the core EFs: conflict monitoring, response inhibition, set-shifting, and working memory updating. We recruited adults with self-reported everyday EFs complaints and formed two groups: one with attention deficit hyperactivity disorder (ADHD) (n=27) and another without any diagnosis (n=22), and compared them to controls (n=21) on the Stroop, Stop-signal, Switching, and N-back task using EEG. Power and functional connectivity analyses were conducted for four regions of interest: frontal-midline, frontolateral left and right, and parietal region. For all four EFs, the groups showed a dynamical increase in theta power over time in the four regions of interest, as well as in functional theta connectivity between these regions. Group differences were found especially for conflict monitoring, with differences in theta power in the frontal-midline and frontolateral right region. These neural markers are also associated with behavioural performance and complaints in daily life. For set-shifting, group differences were less pronounced and for response inhibition and working memory updating no group differences were observed.

摘要

执行功能(EFs)障碍在各种心理障碍中很常见。对EFs背后的神经振荡进行研究,有可能有助于理解这些障碍,并为干预措施的开发做出贡献。本研究的目的是评估核心EFs(冲突监测、反应抑制、任务转换和工作记忆更新)上级网络区域传感器空间中的θ波功率和功能性θ连接。我们招募了有日常EFs自我报告症状的成年人,并将他们分为两组:一组患有注意力缺陷多动障碍(ADHD)(n = 27),另一组未被诊断出任何疾病(n = 22),并使用脑电图将他们与对照组(n = 21)在Stroop、停止信号、转换和n-back任务上进行比较。对四个感兴趣区域进行了功率和功能连接性分析:额中线、左右额外侧和顶叶区域。对于所有四项EFs,两组在四个感兴趣区域以及这些区域之间的功能性θ连接中,θ波功率均随时间动态增加。尤其在冲突监测方面发现了组间差异,表现为额中线和右侧额外侧区域的θ波功率不同。这些神经标志物也与日常生活中的行为表现和症状相关。在任务转换方面,组间差异不太明显,在反应抑制和工作记忆更新方面未观察到组间差异。

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