Kirby R F, Callahan M F, Johnson A K
Department of Psychology, University of Iowa, Iowa City 52242.
J Auton Nerv Syst. 1987 Aug;20(2):185-8. doi: 10.1016/0165-1838(87)90116-0.
The regional vascular responses to an acute intermittent footshock stressor were examined in Wistar-Kyoto and spontaneously hypertensive rats using the pulsed Doppler flow probe method. While both strains exhibited vascular resistance changes, which were typical of the 'defense response', the changes in regional vascular resistance were exaggerated in the spontaneously hypertensive rats compared to the Wistar-Kyoto. Despite these alterations in vascular resistance, and greater increases in heart rate in the spontaneously hypertensive rats, there were no differences in the pressor responses footshock between the Wistar-Kyoto and spontaneously hypertensive rats. These findings indicate that very specific regional hemodynamic changes accompany the characteristic sympathetic nervous system hyperresponsiveness of spontaneously hypertensive rats to environmental stress.
使用脉冲多普勒血流探头法，在Wistar-Kyoto大鼠和自发性高血压大鼠中检测了区域血管对急性间歇性足部电击应激源的反应。虽然两种品系的大鼠均表现出血管阻力变化，这是“防御反应”的典型特征，但与Wistar-Kyoto大鼠相比，自发性高血压大鼠的区域血管阻力变化更为明显。尽管存在这些血管阻力变化，且自发性高血压大鼠的心率升高幅度更大，但Wistar-Kyoto大鼠和自发性高血压大鼠对足部电击的升压反应并无差异。这些发现表明，自发性高血压大鼠对环境应激的特征性交感神经系统高反应性伴随着非常特定的区域血流动力学变化。
