Di Nicolantonio R
Department of Physiology, University of Melbourne, Parkville, Victoria, Australia.
J Hypertens. 1987 Aug;5(4):413-6.
An examination has been made of the blood pressure (BP), saline preference and circulating renin-angiotensin system of spontaneously hypertensive rats (SHR) of the Okamoto strain, normotensive Sprague-Dawley (SD) rats, SHR suckled from immediately after birth on an SD foster mother (SHR-on-SD) and SD cross-suckled on an SHR foster mother (SD-on-SHR). While the BP of SD-on-SHR was not significantly different from that of control SD, SHR-on-SD had significantly lower BP than SHR suckled on their natural mothers. In two-bottle preference tests, neither the saline preference nor total fluid intake of cross-suckled SHR was significantly different from that of SHR controls. While the total fluid intake of SD-on-SHR was not different from that of SD controls, the saline preference of cross-suckled SD was significantly lower than that of control SD. The heart, adrenal and kidney weights of SHR were significantly greater than those of SD, but there were no significant differences between cross-suckled rats and their respective controls. There were no significant differences in plasma renin activity (PRA) or angiotensin converting enzyme (ACE) activity between any groups and these variables did not correlate with each other, with BP or with saline preference. Thus, some factor transferred from the SHR mother postnatally is required for full expression of the elevated BP, but not the exaggerated saline preference of the SHR. Conversely, the saline preference of SD, but not the BP, is altered by cross-suckling.
对冈本品系的自发性高血压大鼠（SHR）、正常血压的斯普拉格-道利（SD）大鼠、出生后立即由SD代乳母哺育的SHR（SHR-on-SD）以及由SHR代乳母交叉哺育的SD（SD-on-SHR）的血压（BP）、盐水偏好和循环肾素-血管紧张素系统进行了检测。虽然SD-on-SHR的血压与对照SD大鼠的血压无显著差异，但SHR-on-SD的血压显著低于由其亲生母亲哺育的SHR。在双瓶偏好试验中，交叉哺育的SHR的盐水偏好和总液体摄入量与SHR对照组均无显著差异。虽然SD-on-SHR的总液体摄入量与SD对照组无差异，但交叉哺育的SD的盐水偏好显著低于对照SD。SHR的心脏、肾上腺和肾脏重量显著大于SD，但交叉哺育的大鼠与其各自的对照组之间无显著差异。任何组之间的血浆肾素活性（PRA）或血管紧张素转换酶（ACE）活性均无显著差异，且这些变量彼此之间、与血压或与盐水偏好均无相关性。因此，出生后从SHR母亲传递的某些因素是SHR血压升高充分表达所必需的，但不是其夸张的盐水偏好所必需的。相反，交叉哺育会改变SD的盐水偏好，但不会改变其血压。
