Department of Urology, Liangxiang Hospital of Beijing Fangshan District, Beijing, China.
Department of Urology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Neurol Res. 2023 Jun;45(6):520-529. doi: 10.1080/01616412.2022.2162223. Epub 2023 Jan 22.
The treatment of neurogenic bladder (NB) is a challenge because conventional therapy often fails. Sacral neuromodulation (SNM) is a minimally invasive technique and an unconventional treatment for neurogenic bladder. Its research is still in the exploratory stage. The research on its effectiveness and safety is not clear.
To assess the effectiveness and safety of sacral neuromodulation (SNM) for neurogenic bladder (NB).
By searching the PubMed databases and Cochrane Library databases, combined with the method of literature tracing, the clinical researches and works on neurogenic bladder and sacral neuromodulation therapy were collected. Two reviewers independently selected and extracted data, (1) determine whether the study meets the inclusion criteria and exclude the literature that meets the exclusion criteria. (2) Researchers' screening results and data, if there are differences in the results, will be discussed to eliminate the differences. (3) Read the full text of the literature carefully to determine the final literature to be included. (4) The relevant data of 11 independent studies, a total of 291 patients, were systematically reviewed using review manager 5.3 software.
This research included 11 independent studies with a total of 291 patients. The improvements of main outcomes before and after SNM therapy were significant: incontinence episodes /24 h (WMD -2.52; 95%CI-3.14-1.90; <0.001), frequency/24 h (WMD-5.96; 95%CI -6.27，-5.66; <0.001), voiding volume (WMD 116.09 mL; 95%CI 86.68，145.51; <0.001), cystometric capacity (WMD 129.84 mL; 95%CI 100.53, 159.15; <0.001), post-void residual volume (WMD-198.00 mL; 95%CI-264.60, -131.40; <0.001), clean intermittent self-catheterization/24 h (WMD-2.48; 95%CI -2.96, -2.00; <0.001).
This systematic review indicated that the sacral neuromodulation treatment for neurogenic bladder was effective and safe.
神经源性膀胱（NB）的治疗是一个挑战，因为常规治疗往往失败。骶神经调节（SNM）是一种微创技术，也是治疗神经源性膀胱的非常规方法。其研究仍处于探索阶段。其有效性和安全性的研究尚不清楚。
评估骶神经调节（SNM）治疗神经源性膀胱（NB）的有效性和安全性。
通过检索 PubMed 数据库和 Cochrane 图书馆数据库，并结合文献追溯方法，收集了关于神经源性膀胱和骶神经调节治疗的临床研究和著作。两位评审员独立选择和提取数据，（1）确定研究是否符合纳入标准，并排除符合排除标准的文献。（2）如果研究人员的筛选结果和数据存在差异，将进行讨论以消除差异。（3）仔细阅读文献全文，以确定最终纳入的文献。（4）使用 Review Manager 5.3 软件系统地回顾了 11 项独立研究的 291 名患者的相关数据。
这项研究包括 11 项独立研究，共 291 名患者。SNM 治疗前后主要结局的改善具有统计学意义：失禁发作/24 小时（WMD-2.52；95%CI-3.14-1.90；<0.001），频率/24 小时（WMD-5.96；95%CI-6.27，-5.66；<0.001），排尿量（WMD 116.09 毫升；95%CI 86.68，145.51；<0.001），膀胱测压容量（WMD 129.84 毫升；95%CI 100.53，159.15；<0.001），残余尿量（WMD-198.00 毫升；95%CI-264.60，-131.40；<0.001），清洁间歇性自我导尿/24 小时（WMD-2.48；95%CI-2.96，-2.00；<0.001）。
本系统评价表明，骶神经调节治疗神经源性膀胱有效且安全。
