Department of Ophthalmology, Boston Children's Hospital, Boston, MA, USA.
Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Semin Ophthalmol. 2023 Jul;38(5):427-432. doi: 10.1080/08820538.2023.2168485. Epub 2023 Jan 22.
A critical review of mechanisms of action and pharmacokinetics of nerve growth factor (NGF), including topical administration, and the studies showing the NGF treatment for anterior and posterior segment diseases in adult and pediatric population are summarized in our paper. Nerve growth factor is commonly used for many different ocular conditions in the adult population to promote nerve regeneration or cellular rescue. Clinical trials for recombinant human NGF have also treated several challenging ocular conditions, such as neurotrophic keratopathy, glaucoma, and retinitis pigmentosa with cystoid macular edema. The safety and efficacy of NGF have been demonstrated in pediatric patients as well. This leads us to consider new applications of NGF for the treatment of pediatric eye diseases.
我们的论文综述了神经生长因子（NGF）的作用机制和药代动力学的研究进展，包括局部给药，以及表明 NGF 治疗成人和儿科人群前节和后节疾病的研究。神经生长因子常用于治疗成人的多种眼部疾病，以促进神经再生或细胞保护。用于治疗神经保护性角膜病变、青光眼和伴有囊样黄斑水肿的色素性视网膜炎等多种挑战性眼部疾病的重组人 NGF 的临床试验也取得了一定效果。在儿科患者中，NGF 的安全性和有效性也得到了证实。这使我们考虑将 NGF 用于治疗儿科眼病的新应用。
