Shafiee Neda, Kordi Negin, Gadruni Keivan, SalehFard Ziba, Jung Friedrich, Heidari Naser
Department of Sport Physiology, Faculty of Sport Sciences, The University of Mazandaran, Babolsar, Iran.
Department of Exercise Physiology, Faculty of Sport Sciences, Razi University, Kermanshah, Iran.
Clin Hemorheol Microcirc. 2023;83(3):305-314. doi: 10.3233/CH-221605.
Physical training in patients with heart failure can affect hemodynamic, cardiac and angiogenesis parameters.
The aim of the present study was to investigate the effects of traditional moderate-intensity rehabilitation training and interval training on some angiogenesis factors in coronary artery bypass graft (CABG) patients.
Thirty CABG patients (mean age±SD, 55±3 years) were randomly assigned to one of three groups: high-intensity interval training (HIIT) or moderate-intensity continuous training (MICT) or the control group. After the initial assessments, eligible patients in the experimental groups (HIIT and MICT) performed exercise training for 8 weeks, while the control group did not. Angiogenesis and angiostatic indices, including pro-adrenomedullin (pro-ADM), basic fibroblast growth factor (bFGF), and endostatin, were then measured.
The results showed no significant difference between pro-ADM in the HIIT and MICT groups (P = 0.99), but a significant difference was found between MICT and the control group and between HIIT and the control group (P = 0.001). There is also no significant difference between the bFGF levels in the HIIT and MICT training groups (P = 1.00), but the changes in this factor between the training groups and the control group were significant (P = 0.001). There was a significant difference between the levels of endostatin in all three groups.
Two methods of cardiac rehabilitation (HIIT and MICT) may be useful for the recovery of patients with coronary artery bypass grafting. This improvement manifested itself in changes in angiogenesis and angiostatic indices in this study. However, more extensive studies are needed to investigate the effects of these two types of rehabilitation programs on other indicators of angiogenesis and angiostatic.
心力衰竭患者的体育锻炼可影响血流动力学、心脏及血管生成参数。
本研究旨在探讨传统中等强度康复训练和间歇训练对冠状动脉旁路移植术（CABG）患者某些血管生成因子的影响。
30例CABG患者（平均年龄±标准差，55±3岁）被随机分为三组之一：高强度间歇训练（HIIT）组、中等强度持续训练（MICT）组或对照组。在初始评估后，实验组（HIIT组和MICT组）符合条件的患者进行8周的运动训练，而对照组不进行训练。然后测量血管生成和血管抑制指标，包括前肾上腺髓质素（pro-ADM）、碱性成纤维细胞生长因子（bFGF）和内皮抑素。
结果显示，HIIT组和MICT组的pro-ADM之间无显著差异（P = 0.99），但MICT组与对照组之间以及HIIT组与对照组之间存在显著差异（P = 0.001）。HIIT组和MICT训练组的bFGF水平也无显著差异（P = 1.00），但训练组与对照组之间该因子的变化具有显著性（P = 0.001）。三组的内皮抑素水平存在显著差异。
两种心脏康复方法（HIIT和MICT）可能有助于冠状动脉旁路移植术患者的康复。在本研究中，这种改善表现为血管生成和血管抑制指标的变化。然而，需要更广泛的研究来调查这两种康复方案对血管生成和血管抑制的其他指标的影响。
